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• W1995235498 abstract "Recent data have shown that synthetic polymers and nanomaterials display phenotypic effects in cells and signal transduction mechanisms involved in inflammation, differentiation, proliferation, and apoptosis.This article aims to investigate the effect of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) block copolymers with a wide range of biomedical and pharmaceutical applications on apoptosis and/or cell immortalization, by flow cytometry and multiplex RT-PCR for bax, bcl-2, and human telomerase reverse transcriptase (hTERT).PEO-PPO amphiphiles upregulated bax and hTERT and induced apoptosis of two human hepatoma cell lines.PEO-PPO block copolymers-considered safe for human use-can drastically alter gene expression profiles of genes related to apoptosis/cell proliferation." @default.
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• W1995235498 date "2015-05-14" @default.
• W1995235498 modified "2023-10-06" @default.
• W1995235498 title "Effect of several PEO-PPO amphiphiles on<i>bax</i>,<i>bcl-2</i>, and<i>hTERT</i>mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients" @default.
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• W1995235498 doi "https://doi.org/10.1002/bab.1352" @default.
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