Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995241918> ?p ?o ?g. }
- W1995241918 endingPage "864" @default.
- W1995241918 startingPage "851" @default.
- W1995241918 abstract "Serotonin (5-HT) has been implicated in the control of eating behavior and body weight. Stimulants of this monoamine reduce food intake and weight gain and increase energy expenditure, both in animals and in humans. This article reviews evidence that supports a role for hypothalamic serotonergic receptor mechanisms in the mediation of these effects. A variety of studies in rodents indicate that, at low doses, 5-HT or drugs that enhance the release of this neurotransmitter preferentially inhibit the ingestion of carbohydrate, more than fat or protein. This phenomenon is mediated, in part, by 5-HT receptors located in various medial hypothalamic nuclei. A negative feedback loop exists between the consumption of this macronutrient and the turnover of 5-HT in the hypothalamus. That is, carbohydrate ingestion enhances the synthesis and release of hypothalamic 5-HT, which in turn serves to control the size of carbohydrate-rich meals. A model is described that proposes the involvement of circulating hormones and glucose in this feedback process. These hormones, including insulin, corticosterone, and the adipose tissue-derived hormone, leptin, have impact on serotonergic function as well as satiety. This model further suggests that 5-HT exerts its strongest effect on appetite at the start of the natural feeding cycle, when carbohydrate is normally preferred. Clinical studies provide evidence that is consistent with the proposed model and that implicates 5-HT in disturbances of eating and body weight disorders." @default.
- W1995241918 created "2016-06-24" @default.
- W1995241918 creator A5045559088 @default.
- W1995241918 creator A5090507281 @default.
- W1995241918 date "1998-11-01" @default.
- W1995241918 modified "2023-10-13" @default.
- W1995241918 title "Hypothalamic serotonin in control of eating behavior, meal size, and body weight" @default.
- W1995241918 cites W1480003601 @default.
- W1995241918 cites W1486463812 @default.
- W1995241918 cites W1569613926 @default.
- W1995241918 cites W1723045120 @default.
- W1995241918 cites W1942155885 @default.
- W1995241918 cites W1963722329 @default.
- W1995241918 cites W1963919733 @default.
- W1995241918 cites W1964042817 @default.
- W1995241918 cites W1964672426 @default.
- W1995241918 cites W1966198879 @default.
- W1995241918 cites W1966528606 @default.
- W1995241918 cites W1967501438 @default.
- W1995241918 cites W1967731925 @default.
- W1995241918 cites W1967742713 @default.
- W1995241918 cites W1969964748 @default.
- W1995241918 cites W1970899891 @default.
- W1995241918 cites W1971843117 @default.
- W1995241918 cites W1973852095 @default.
- W1995241918 cites W1974760551 @default.
- W1995241918 cites W1975591406 @default.
- W1995241918 cites W1978375148 @default.
- W1995241918 cites W1979714516 @default.
- W1995241918 cites W1981199565 @default.
- W1995241918 cites W1986398415 @default.
- W1995241918 cites W1986644684 @default.
- W1995241918 cites W1987376546 @default.
- W1995241918 cites W1988591340 @default.
- W1995241918 cites W1989719288 @default.
- W1995241918 cites W1991515315 @default.
- W1995241918 cites W1992146642 @default.
- W1995241918 cites W1992241048 @default.
- W1995241918 cites W1992400243 @default.
- W1995241918 cites W1996713062 @default.
- W1995241918 cites W2001660140 @default.
- W1995241918 cites W2002665566 @default.
- W1995241918 cites W2004509841 @default.
- W1995241918 cites W2005759584 @default.
- W1995241918 cites W2005770401 @default.
- W1995241918 cites W2009269728 @default.
- W1995241918 cites W2009968514 @default.
- W1995241918 cites W2010087213 @default.
- W1995241918 cites W2011986959 @default.
- W1995241918 cites W2014014450 @default.
- W1995241918 cites W2016381466 @default.
- W1995241918 cites W2016448819 @default.
- W1995241918 cites W2016541433 @default.
- W1995241918 cites W2019219354 @default.
- W1995241918 cites W2020063446 @default.
- W1995241918 cites W2022288151 @default.
- W1995241918 cites W2023037697 @default.
- W1995241918 cites W2023100523 @default.
- W1995241918 cites W2026677009 @default.
- W1995241918 cites W2027718546 @default.
- W1995241918 cites W2029141930 @default.
- W1995241918 cites W2029881171 @default.
- W1995241918 cites W2030608385 @default.
- W1995241918 cites W2031487890 @default.
- W1995241918 cites W2031733754 @default.
- W1995241918 cites W2032435910 @default.
- W1995241918 cites W2035632600 @default.
- W1995241918 cites W2038241629 @default.
- W1995241918 cites W2040556628 @default.
- W1995241918 cites W2041457090 @default.
- W1995241918 cites W2041504277 @default.
- W1995241918 cites W2042288907 @default.
- W1995241918 cites W2043105055 @default.
- W1995241918 cites W2044031239 @default.
- W1995241918 cites W2046856431 @default.
- W1995241918 cites W2048437805 @default.
- W1995241918 cites W2048818825 @default.
- W1995241918 cites W2049215043 @default.
- W1995241918 cites W2049569798 @default.
- W1995241918 cites W2051523199 @default.
- W1995241918 cites W2052018584 @default.
- W1995241918 cites W2056075979 @default.
- W1995241918 cites W2056503433 @default.
- W1995241918 cites W2058716914 @default.
- W1995241918 cites W2059279128 @default.
- W1995241918 cites W2060548224 @default.
- W1995241918 cites W2062128661 @default.
- W1995241918 cites W2065630583 @default.
- W1995241918 cites W2069445850 @default.
- W1995241918 cites W2069851163 @default.
- W1995241918 cites W2071013125 @default.
- W1995241918 cites W2071054705 @default.
- W1995241918 cites W2071465918 @default.
- W1995241918 cites W2073647125 @default.
- W1995241918 cites W2073953400 @default.
- W1995241918 cites W2074514894 @default.
- W1995241918 cites W2075019242 @default.
- W1995241918 cites W2075292017 @default.