Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995243351> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1995243351 endingPage "905" @default.
- W1995243351 startingPage "897" @default.
- W1995243351 abstract "Epidemiological studies have indicated that exposure to particle matter (PM) increased the risk of respiratory and cardiovascular morbidity and mortality. It is suggested that PM smaller than 2.5 μm in aerodynamic diameter (PM2.5) may contribute to these responses. However, the molecular mechanism is still unknown. To elucidate the changes in molecular level, we investigated the gene expression profile of concentrated ambient particles (CAPs)-exposed rats. Aged F344 rats were exposed with CAPs (594 μg/m3) or clean air 4 h per day for 3 days, and lung and heart tissues were then excised for DNA microarray analysis. Expression profiles related to inflammation and blood pressure regulation revealed differential expression of 7 genes in the lung and that of 3 genes in the heart ventricle. According to the complement activation-associated genes, complement factor B (Bf), complement component 2 and 4a (C4a), and C1 inhibitor genes were up-regulated in CAPs-exposed rat lung. Bf and C4a genes were also up-regulated in the heart. These suggest the treated animal ready for production of these proteins when activation of complement cascade is required. Pro-inflammatory cytokine, interleukin-1β, was also up-regulated in CAPs-exposed rat lung. Gene related with blood pressure regulation (angiotensin I converting enzyme) was also up-regulated in CAPs-exposed rat lung. Negative regulator of blood pressure (neuropeptide Y) was down-regulated in CAPs-exposed rat heart. These results indicate that CAPs may affect respiratory and cardiovascular organs by activation of inflammatory responses and disintegration of blood pressure regulation in early stage of CAPs exposure." @default.
- W1995243351 created "2016-06-24" @default.
- W1995243351 creator A5010277722 @default.
- W1995243351 creator A5036188375 @default.
- W1995243351 creator A5062162291 @default.
- W1995243351 date "2011-11-29" @default.
- W1995243351 modified "2023-09-27" @default.
- W1995243351 title "Differential gene expression associated with inflammation and blood pressure regulation induced by concentrated ambient particle exposure" @default.
- W1995243351 cites W1978287806 @default.
- W1995243351 cites W1993367380 @default.
- W1995243351 cites W2015002238 @default.
- W1995243351 cites W2017941138 @default.
- W1995243351 cites W2024762092 @default.
- W1995243351 cites W2025772648 @default.
- W1995243351 cites W2038343834 @default.
- W1995243351 cites W2063164636 @default.
- W1995243351 cites W2091733516 @default.
- W1995243351 cites W2120897467 @default.
- W1995243351 cites W2142825015 @default.
- W1995243351 cites W2147642684 @default.
- W1995243351 cites W2155118487 @default.
- W1995243351 cites W2157762149 @default.
- W1995243351 cites W2166431337 @default.
- W1995243351 cites W2166604768 @default.
- W1995243351 cites W2170484912 @default.
- W1995243351 doi "https://doi.org/10.3109/08958378.2011.625058" @default.
- W1995243351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22122303" @default.
- W1995243351 hasPublicationYear "2011" @default.
- W1995243351 type Work @default.
- W1995243351 sameAs 1995243351 @default.
- W1995243351 citedByCount "11" @default.
- W1995243351 countsByYear W19952433512013 @default.
- W1995243351 countsByYear W19952433512015 @default.
- W1995243351 countsByYear W19952433512016 @default.
- W1995243351 countsByYear W19952433512018 @default.
- W1995243351 countsByYear W19952433512019 @default.
- W1995243351 countsByYear W19952433512020 @default.
- W1995243351 crossrefType "journal-article" @default.
- W1995243351 hasAuthorship W1995243351A5010277722 @default.
- W1995243351 hasAuthorship W1995243351A5036188375 @default.
- W1995243351 hasAuthorship W1995243351A5062162291 @default.
- W1995243351 hasConcept C104317684 @default.
- W1995243351 hasConcept C111684460 @default.
- W1995243351 hasConcept C126322002 @default.
- W1995243351 hasConcept C134018914 @default.
- W1995243351 hasConcept C150194340 @default.
- W1995243351 hasConcept C203014093 @default.
- W1995243351 hasConcept C2776914184 @default.
- W1995243351 hasConcept C2777714996 @default.
- W1995243351 hasConcept C55493867 @default.
- W1995243351 hasConcept C71924100 @default.
- W1995243351 hasConcept C86803240 @default.
- W1995243351 hasConcept C8891405 @default.
- W1995243351 hasConcept C90582226 @default.
- W1995243351 hasConceptScore W1995243351C104317684 @default.
- W1995243351 hasConceptScore W1995243351C111684460 @default.
- W1995243351 hasConceptScore W1995243351C126322002 @default.
- W1995243351 hasConceptScore W1995243351C134018914 @default.
- W1995243351 hasConceptScore W1995243351C150194340 @default.
- W1995243351 hasConceptScore W1995243351C203014093 @default.
- W1995243351 hasConceptScore W1995243351C2776914184 @default.
- W1995243351 hasConceptScore W1995243351C2777714996 @default.
- W1995243351 hasConceptScore W1995243351C55493867 @default.
- W1995243351 hasConceptScore W1995243351C71924100 @default.
- W1995243351 hasConceptScore W1995243351C86803240 @default.
- W1995243351 hasConceptScore W1995243351C8891405 @default.
- W1995243351 hasConceptScore W1995243351C90582226 @default.
- W1995243351 hasIssue "14" @default.
- W1995243351 hasLocation W19952433511 @default.
- W1995243351 hasLocation W19952433512 @default.
- W1995243351 hasOpenAccess W1995243351 @default.
- W1995243351 hasPrimaryLocation W19952433511 @default.
- W1995243351 hasRelatedWork W2003213334 @default.
- W1995243351 hasRelatedWork W2009966535 @default.
- W1995243351 hasRelatedWork W2028564053 @default.
- W1995243351 hasRelatedWork W2056036087 @default.
- W1995243351 hasRelatedWork W2063082931 @default.
- W1995243351 hasRelatedWork W2072845881 @default.
- W1995243351 hasRelatedWork W2129462573 @default.
- W1995243351 hasRelatedWork W2164347610 @default.
- W1995243351 hasRelatedWork W2886366480 @default.
- W1995243351 hasRelatedWork W4232831581 @default.
- W1995243351 hasVolume "23" @default.
- W1995243351 isParatext "false" @default.
- W1995243351 isRetracted "false" @default.
- W1995243351 magId "1995243351" @default.
- W1995243351 workType "article" @default.