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- W1995250930 abstract "Abstract The degree of syndecan-1 shed from the surface of airway epithelial cells upon infection with Streptococcus pneumoniae regulated host local resistance during the initial phase of infection. Higher levels of syndecan-1 shedding elicited the polymorphonuclear cell-oriented local response, while low degrees of the shedding induced mononuclear cell-oriented response. Higher levels of leukocyte accumulation at the infectious site affected local tissue damage, particularly the perivascular area, thereby allowing the pathogens to enter into the bloodstream. This difference might be primarily a cause of, but not a result from, different host resistance, since mice devoid of syndecan-1 were highly susceptible to the infection. The present study therefore suggests that syndecan shedding during the initial phase of microbial attachment regulates local host response, the degree and nature of which in turn may determine the subsequent host resistance." @default.
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- W1995250930 date "2003-12-01" @default.
- W1995250930 modified "2023-10-14" @default.
- W1995250930 title "Syndecan shedding from epithelial cells affects host defense against respiratory infection" @default.
- W1995250930 cites W1964056927 @default.
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- W1995250930 doi "https://doi.org/10.1016/s0531-5131(03)01417-1" @default.
- W1995250930 hasPublicationYear "2003" @default.
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