FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995257608> ?p ?o ?g. }

• W1995257608 endingPage "1267" @default.
• W1995257608 startingPage "1259" @default.
• W1995257608 abstract "Adrenomedullin (AM) is a newly discovered peptide that has a potent vasorelaxant activity. To investigate its potential roles in hypoxia-induced renal injury, we examined whether AM production in the kidney increased under hypoxic conditions.The AM transcript levels in Madin-Darby canine kidney (MDCK) cells, rat vascular smooth muscle cells (VSMCs), and rat mesangial cells were assessed by Northern blot analyses under normoxic and hypoxic conditions. The AM peptide in culture media was measured by radioimmunoassay. The effects of hypoxia on accumulation of cAMP in VSMCs were also examined. The stability of AM transcripts under normoxic and hypoxic conditions was compared in the presence of actinomycin D. The effects of hypoxia on AM promoter activity was assessed by transient transfection assays using the AM promoter subcloned upstream of luciferase gene.The expression of AM transcripts increased significantly in MDCK cells, rat VSMCs, and rat mesangial cells under hypoxic conditions without changes in the stability of AM transcripts; however, the AM promoter activity under hypoxic was not elevated significantly. The accumulation of AM peptide in culture media also increased significantly under hypoxic conditions in MDCK cells (2.2 +/- 0.1 fmol/10(5) cells in normoxia vs. 3.5 +/- 0.3 fmol/10(5) cells in hypoxia, 6 hr after hypoxia induction, P < 0.001), and in rat VSMCs (5.5 +/- 0.3 fmol/10(5) cells in normoxia vs. 7.8 +/- 0.4 fmol/10(5) cells in hypoxia, 8 hr after hypoxia induction, P < 0.01). Under hypoxic conditions, cAMP levels in rat VSMCs increased significantly compared with those under normoxic conditions (13.3 +/- 1.4 pmol/well vs. 4.6 +/- 0.4 pmol/well, P < 0.01).Renal parenchymal cells as well as renal vessels may produce AM under hypoxic conditions." @default.
• W1995257608 created "2016-06-24" @default.
• W1995257608 creator A5001062336 @default.
• W1995257608 creator A5002264588 @default.
• W1995257608 creator A5006782913 @default.
• W1995257608 creator A5021763876 @default.
• W1995257608 creator A5023178862 @default.
• W1995257608 creator A5026150031 @default.
• W1995257608 creator A5028775406 @default.
• W1995257608 creator A5032400721 @default.
• W1995257608 creator A5034244372 @default.
• W1995257608 creator A5068354355 @default.
• W1995257608 creator A5085467021 @default.
• W1995257608 creator A5091003441 @default.
• W1995257608 date "1999-04-01" @default.
• W1995257608 modified "2023-10-16" @default.
• W1995257608 title "Hypoxia-induced adrenomedullin production in the kidney" @default.
• W1995257608 cites W1503667331 @default.
• W1995257608 cites W1521696202 @default.
• W1995257608 cites W1966932577 @default.
• W1995257608 cites W1967701704 @default.
• W1995257608 cites W1976999762 @default.
• W1995257608 cites W1977944024 @default.
• W1995257608 cites W1982290807 @default.
• W1995257608 cites W1987989887 @default.
• W1995257608 cites W1988403143 @default.
• W1995257608 cites W2002017720 @default.
• W1995257608 cites W2003726337 @default.
• W1995257608 cites W2004887716 @default.
• W1995257608 cites W2008856935 @default.
• W1995257608 cites W2012035711 @default.
• W1995257608 cites W2023541036 @default.
• W1995257608 cites W2038449972 @default.
• W1995257608 cites W2043034527 @default.
• W1995257608 cites W2046787212 @default.
• W1995257608 cites W2052501155 @default.
• W1995257608 cites W2054385742 @default.
• W1995257608 cites W2056803964 @default.
• W1995257608 cites W2060000931 @default.
• W1995257608 cites W2061114894 @default.
• W1995257608 cites W2071839843 @default.
• W1995257608 cites W2083381610 @default.
• W1995257608 cites W2090627731 @default.
• W1995257608 cites W2090850356 @default.
• W1995257608 cites W2092419989 @default.
• W1995257608 cites W2111112233 @default.
• W1995257608 cites W2122831226 @default.
• W1995257608 cites W2150753236 @default.
• W1995257608 cites W2158979977 @default.
• W1995257608 cites W2166431178 @default.
• W1995257608 doi "https://doi.org/10.1046/j.1523-1755.1999.00361.x" @default.
• W1995257608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10200989" @default.
• W1995257608 hasPublicationYear "1999" @default.
• W1995257608 type Work @default.
• W1995257608 sameAs 1995257608 @default.
• W1995257608 citedByCount "81" @default.
• W1995257608 countsByYear W19952576082012 @default.
• W1995257608 countsByYear W19952576082013 @default.
• W1995257608 countsByYear W19952576082014 @default.
• W1995257608 countsByYear W19952576082015 @default.
• W1995257608 countsByYear W19952576082016 @default.
• W1995257608 countsByYear W19952576082018 @default.
• W1995257608 countsByYear W19952576082019 @default.
• W1995257608 countsByYear W19952576082020 @default.
• W1995257608 countsByYear W19952576082021 @default.
• W1995257608 crossrefType "journal-article" @default.
• W1995257608 hasAuthorship W1995257608A5001062336 @default.
• W1995257608 hasAuthorship W1995257608A5002264588 @default.
• W1995257608 hasAuthorship W1995257608A5006782913 @default.
• W1995257608 hasAuthorship W1995257608A5021763876 @default.
• W1995257608 hasAuthorship W1995257608A5023178862 @default.
• W1995257608 hasAuthorship W1995257608A5026150031 @default.
• W1995257608 hasAuthorship W1995257608A5028775406 @default.
• W1995257608 hasAuthorship W1995257608A5032400721 @default.
• W1995257608 hasAuthorship W1995257608A5034244372 @default.
• W1995257608 hasAuthorship W1995257608A5068354355 @default.
• W1995257608 hasAuthorship W1995257608A5085467021 @default.
• W1995257608 hasAuthorship W1995257608A5091003441 @default.
• W1995257608 hasBestOaLocation W19952576081 @default.
• W1995257608 hasConcept C104317684 @default.
• W1995257608 hasConcept C105580179 @default.
• W1995257608 hasConcept C126322002 @default.
• W1995257608 hasConcept C134018914 @default.
• W1995257608 hasConcept C153911025 @default.
• W1995257608 hasConcept C170493617 @default.
• W1995257608 hasConcept C176685330 @default.
• W1995257608 hasConcept C177707886 @default.
• W1995257608 hasConcept C178790620 @default.
• W1995257608 hasConcept C185592680 @default.
• W1995257608 hasConcept C2776415932 @default.
• W1995257608 hasConcept C2777152744 @default.
• W1995257608 hasConcept C2779395532 @default.
• W1995257608 hasConcept C2780091579 @default.
• W1995257608 hasConcept C2992686903 @default.
• W1995257608 hasConcept C540031477 @default.
• W1995257608 hasConcept C54009773 @default.
• W1995257608 hasConcept C54355233 @default.
• W1995257608 hasConcept C55493867 @default.

• next