FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995260063> ?p ?o ?g. }

• W1995260063 endingPage "170" @default.
• W1995260063 startingPage "163" @default.
• W1995260063 abstract "The inhalation of many types of chemicals, including pesticides, perfumes, and other low-molecular weight chemicals, is a leading cause of allergic respiratory diseases. We attempted to develop a new test protocol to detect environmental chemical-related respiratory hypersensitivity at low and weakly immunogenic doses. We used long-term dermal sensitization followed by a low-dose intratracheal challenge to evaluate sensitization by the well-known respiratory sensitizers trimellitic anhydride (TMA) and toluene diisocyanate (TDI) and the contact sensitizer 2,4-dinitrochlorobenzene (DNCB). After topically sensitizing BALB/c mice (9 times in 3 weeks) and challenging them intratracheally with TMA, TDI, or DNCB, we assayed differential cell counts and chemokine levels in bronchoalveolar lavage fluid (BALF); lymphocyte counts, surface antigen expression of B cells, and local cytokine production in lung-associated lymph nodes (LNs); and antigen-specific IgE levels in serum and BALF. TMA induced marked increases in antigen-specific IgE levels in both serum and BALF, proliferation of eosinophils and chemokines (MCP-1, eotaxin, and MIP-1beta) in BALF, and proliferation of Th2 cytokines (interleukin (IL)-4, IL-10, and IL-13) in restimulated LN cells. TDI induced marked increases in levels of cytokines (IL-4, IL-10, IL-13, and IFN-gamma) produced by restimulated LN cells. In contrast, DNCB treatment yielded, at most, small, nonsignificant increases in all parameters. Our protocol thus detected respiratory allergic responses to low-molecular weight chemicals and may be useful for detecting environmental chemical-related respiratory allergy." @default.
• W1995260063 created "2016-06-24" @default.
• W1995260063 creator A5006246866 @default.
• W1995260063 creator A5016358005 @default.
• W1995260063 creator A5018420164 @default.
• W1995260063 creator A5035904712 @default.
• W1995260063 creator A5036863557 @default.
• W1995260063 creator A5045225512 @default.
• W1995260063 creator A5049295699 @default.
• W1995260063 creator A5087154845 @default.
• W1995260063 date "2008-10-01" @default.
• W1995260063 modified "2023-09-26" @default.
• W1995260063 title "Use of long term dermal sensitization followed by intratracheal challenge method to identify low-dose chemical-induced respiratory allergic responses in mice" @default.
• W1995260063 cites W1661544713 @default.
• W1995260063 cites W1775749144 @default.
• W1995260063 cites W1977554622 @default.
• W1995260063 cites W1980147576 @default.
• W1995260063 cites W1984572258 @default.
• W1995260063 cites W2013002234 @default.
• W1995260063 cites W2014369787 @default.
• W1995260063 cites W2016477869 @default.
• W1995260063 cites W2017458580 @default.
• W1995260063 cites W2017932618 @default.
• W1995260063 cites W2018444641 @default.
• W1995260063 cites W2023949683 @default.
• W1995260063 cites W2024687250 @default.
• W1995260063 cites W2028614748 @default.
• W1995260063 cites W2036571489 @default.
• W1995260063 cites W2037835407 @default.
• W1995260063 cites W2046755721 @default.
• W1995260063 cites W2049312111 @default.
• W1995260063 cites W2053228091 @default.
• W1995260063 cites W2065564501 @default.
• W1995260063 cites W2072557317 @default.
• W1995260063 cites W2074597964 @default.
• W1995260063 cites W2076709090 @default.
• W1995260063 cites W2084424111 @default.
• W1995260063 cites W2087644006 @default.
• W1995260063 cites W2109513456 @default.
• W1995260063 cites W2111196997 @default.
• W1995260063 cites W2112249469 @default.
• W1995260063 cites W2120588301 @default.
• W1995260063 cites W2130243287 @default.
• W1995260063 cites W2134639416 @default.
• W1995260063 cites W2141540939 @default.
• W1995260063 cites W2143885790 @default.
• W1995260063 cites W2149772903 @default.
• W1995260063 cites W2152044788 @default.
• W1995260063 cites W2156615638 @default.
• W1995260063 cites W2156642799 @default.
• W1995260063 cites W2159009676 @default.
• W1995260063 cites W2170211619 @default.
• W1995260063 cites W2172466148 @default.
• W1995260063 cites W2993989422 @default.
• W1995260063 cites W4241446880 @default.
• W1995260063 cites W4255520262 @default.
• W1995260063 cites W4299436651 @default.
• W1995260063 doi "https://doi.org/10.1016/j.toxlet.2008.07.017" @default.
• W1995260063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18708131" @default.
• W1995260063 hasPublicationYear "2008" @default.
• W1995260063 type Work @default.
• W1995260063 sameAs 1995260063 @default.
• W1995260063 citedByCount "13" @default.
• W1995260063 countsByYear W19952600632012 @default.
• W1995260063 countsByYear W19952600632014 @default.
• W1995260063 countsByYear W19952600632016 @default.
• W1995260063 countsByYear W19952600632020 @default.
• W1995260063 crossrefType "journal-article" @default.
• W1995260063 hasAuthorship W1995260063A5006246866 @default.
• W1995260063 hasAuthorship W1995260063A5016358005 @default.
• W1995260063 hasAuthorship W1995260063A5018420164 @default.
• W1995260063 hasAuthorship W1995260063A5035904712 @default.
• W1995260063 hasAuthorship W1995260063A5036863557 @default.
• W1995260063 hasAuthorship W1995260063A5045225512 @default.
• W1995260063 hasAuthorship W1995260063A5049295699 @default.
• W1995260063 hasAuthorship W1995260063A5087154845 @default.
• W1995260063 hasConcept C126322002 @default.
• W1995260063 hasConcept C13373296 @default.
• W1995260063 hasConcept C141105273 @default.
• W1995260063 hasConcept C159654299 @default.
• W1995260063 hasConcept C178790620 @default.
• W1995260063 hasConcept C185592680 @default.
• W1995260063 hasConcept C188027245 @default.
• W1995260063 hasConcept C203014093 @default.
• W1995260063 hasConcept C207480886 @default.
• W1995260063 hasConcept C2776217527 @default.
• W1995260063 hasConcept C2776989157 @default.
• W1995260063 hasConcept C2777714996 @default.
• W1995260063 hasConcept C2777716647 @default.
• W1995260063 hasConcept C2777961210 @default.
• W1995260063 hasConcept C2779578285 @default.
• W1995260063 hasConcept C2781167081 @default.
• W1995260063 hasConcept C534529494 @default.
• W1995260063 hasConcept C71924100 @default.
• W1995260063 hasConcept C8891405 @default.
• W1995260063 hasConceptScore W1995260063C126322002 @default.
• W1995260063 hasConceptScore W1995260063C13373296 @default.
• W1995260063 hasConceptScore W1995260063C141105273 @default.

• next