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• W1995279903 abstract "The synthesis of a poly(ethylene glycol) (PEG)-grafted surface-reactive random copolymer and its self-assembled structure on Si/SiO2 substrates for construction of nonbiofouling surfaces are reported. The copolymer, poly(TMSMA-r-PEGMA), which is comprised of an “anchor part” (trimethoxysilane) and a “function part” (PEG), was synthesized by a radical polymerization reaction. The copolymer spontaneously formed monolayers on Si/SiO2 wafers with average thicknesses of 11 Å. Tapping mode atomic force microscopy (AFM) revealed that the surface of the polymer monolayers was smooth with an average roughness of 1.3 Å (root-mean-square). The protein resistance of the polymer monolayers on Si/SiO2 wafers was evaluated using insulin, lysozyme, and fibrinogen. For all tested proteins, the polymer monolayers showed significant reduction (up to 98%) in nonspecific protein adsorption compared to the unmodified Si/SiO2 wafers. In addition, cell adhesion as probed using 3T3 fibroblasts was significantly reduced on the polymer-coated glass substrates in comparison to unmodified glass substrates." @default.
• W1995279903 created "2016-06-24" @default.
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• W1995279903 date "2003-10-30" @default.
• W1995279903 modified "2023-10-01" @default.
• W1995279903 title "Construction of Nonbiofouling Surfaces by Polymeric Self-Assembled Monolayers" @default.
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• W1995279903 doi "https://doi.org/10.1021/la034839e" @default.
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