FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995280230> ?p ?o ?g. }

• W1995280230 endingPage "253" @default.
• W1995280230 startingPage "240" @default.
• W1995280230 abstract "Despite nearly twenty years of research into the field of ischemic preconditioning, the actual mechanism of protection remains unclear. However, much progress has been made in elucidating the signal transduction pathways that convey the extracellular signal initiated by the preconditioning stimulus to the intracellular targets of cardioprotection, with many of these pathways involving the activation of a diverse array of survival protein kinase cascades. The powerful protective benefits of ischemic preconditioning have not yet been realised in the clinical arena, not least because of the prerequisite for any preconditioning intervention to be applied prior to the onset of index ischemia, which in the case of an acute myocardial infarction is difficult to institute. In this regard, the newly described phenomenon of ischemic postconditioning, which comprises a cardioprotective intervention that can be applied at the time of myocardial reperfusion, offers a far more attractive and amenable approach to myocardial protection. Interestingly, certain survival protein kinase cascades recruited at the time of myocardial reperfusion appear to be shared by both ischemic preconditioning and postconditioning, thereby offering a potentially common target of cardioprotection. The often disputed roles these different protein kinases play in mediating the cardioprotective effects of ischemic preconditioning and postconditioning are reviewed in this article, and include protein kinases C, G, and A, members of the MAPK family (Erk1/2, p38, JNK and BMK1), the PI3K–Akt cascade, and the JAK-STAT pathway." @default.
• W1995280230 created "2016-06-24" @default.
• W1995280230 creator A5014650682 @default.
• W1995280230 creator A5090808868 @default.
• W1995280230 date "2006-05-01" @default.
• W1995280230 modified "2023-10-16" @default.
• W1995280230 title "Survival kinases in ischemic preconditioning and postconditioning" @default.
• W1995280230 cites W1269302828 @default.
• W1995280230 cites W134519975 @default.
• W1995280230 cites W1492401903 @default.
• W1995280230 cites W1967294331 @default.
• W1995280230 cites W1967526945 @default.
• W1995280230 cites W1969868126 @default.
• W1995280230 cites W1973878338 @default.
• W1995280230 cites W1976462601 @default.
• W1995280230 cites W1977661035 @default.
• W1995280230 cites W1979250205 @default.
• W1995280230 cites W1981944954 @default.
• W1995280230 cites W1982312594 @default.
• W1995280230 cites W1983537876 @default.
• W1995280230 cites W1986068964 @default.
• W1995280230 cites W1986905765 @default.
• W1995280230 cites W1990253313 @default.
• W1995280230 cites W1990768361 @default.
• W1995280230 cites W1991490958 @default.
• W1995280230 cites W1991838517 @default.
• W1995280230 cites W1992001259 @default.
• W1995280230 cites W1996081066 @default.
• W1995280230 cites W1999631310 @default.
• W1995280230 cites W1999756074 @default.
• W1995280230 cites W2002384956 @default.
• W1995280230 cites W2004617058 @default.
• W1995280230 cites W2007939778 @default.
• W1995280230 cites W2008767430 @default.
• W1995280230 cites W2009146385 @default.
• W1995280230 cites W2010440482 @default.
• W1995280230 cites W2010512593 @default.
• W1995280230 cites W2014376812 @default.
• W1995280230 cites W2014562241 @default.
• W1995280230 cites W2016113133 @default.
• W1995280230 cites W2017513588 @default.
• W1995280230 cites W2019975211 @default.
• W1995280230 cites W2021111465 @default.
• W1995280230 cites W2024393365 @default.
• W1995280230 cites W2026313838 @default.
• W1995280230 cites W2026951979 @default.
• W1995280230 cites W2029077404 @default.
• W1995280230 cites W2029176648 @default.
• W1995280230 cites W2035060698 @default.
• W1995280230 cites W2042690788 @default.
• W1995280230 cites W2046566019 @default.
• W1995280230 cites W2048020247 @default.
• W1995280230 cites W2048181009 @default.
• W1995280230 cites W2048547503 @default.
• W1995280230 cites W2049043910 @default.
• W1995280230 cites W2061365466 @default.
• W1995280230 cites W2061711733 @default.
• W1995280230 cites W2064510514 @default.
• W1995280230 cites W2067692382 @default.
• W1995280230 cites W2069537903 @default.
• W1995280230 cites W2070732456 @default.
• W1995280230 cites W2072763150 @default.
• W1995280230 cites W2074301028 @default.
• W1995280230 cites W2077172545 @default.
• W1995280230 cites W2078248611 @default.
• W1995280230 cites W2083708483 @default.
• W1995280230 cites W2084980999 @default.
• W1995280230 cites W2087812939 @default.
• W1995280230 cites W2088177561 @default.
• W1995280230 cites W2088596136 @default.
• W1995280230 cites W2089271830 @default.
• W1995280230 cites W2089686093 @default.
• W1995280230 cites W2091471938 @default.
• W1995280230 cites W2092914889 @default.
• W1995280230 cites W2096345670 @default.
• W1995280230 cites W2098719212 @default.
• W1995280230 cites W2102987835 @default.
• W1995280230 cites W2106279971 @default.
• W1995280230 cites W2106829353 @default.
• W1995280230 cites W2116286593 @default.
• W1995280230 cites W2116899872 @default.
• W1995280230 cites W2117344826 @default.
• W1995280230 cites W2117993703 @default.
• W1995280230 cites W2119393589 @default.
• W1995280230 cites W2120007291 @default.
• W1995280230 cites W2122501550 @default.
• W1995280230 cites W2123709832 @default.
• W1995280230 cites W2124027170 @default.
• W1995280230 cites W2127652330 @default.
• W1995280230 cites W2128745548 @default.
• W1995280230 cites W2129932871 @default.
• W1995280230 cites W2130497617 @default.
• W1995280230 cites W2131015734 @default.
• W1995280230 cites W2131755434 @default.
• W1995280230 cites W2132390559 @default.
• W1995280230 cites W2133193775 @default.
• W1995280230 cites W2134313894 @default.
• W1995280230 cites W2134643192 @default.

• next