Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995280565> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1995280565 endingPage "668" @default.
- W1995280565 startingPage "664" @default.
- W1995280565 abstract "Organophosphates (OPs) cause irreversible inhibition of cholinesterases (ChEs) and profound cholinergic stimulation. There are major differences in the response of the dog and cat pancreas to the in vivo administration of Diazinon (0,O-diethy1 0-2-isopropy1-4-methy1-6-pyrimidyl phosphothioate), a butyrylcholinesterase (BuChE) inhibitor. Acute edematous pancreatitis is found in the dog but not in the cat. The present experiments were designed to see what effect OP had in vitro on pancreatic exocrine function of dog, cat, and guinea pig, and whether the effects were consistent with an anti-ChE activity. A water-soluble OP agent, tetraisopropyl pyrophosphoramide (iso-OMPA) at M, which like Diazinon inhibits BuChE, was used. Minced pieces of fresh whole pancreata 3 mm in size were taken from 3 dogs, 4 guinea pigs, and 2 cats. The tissues were placed in flasks containing Eagle's solution and gassed with 100% 02. Cumulative amylase release was measured by Phadebus method up to 3 h. At half-maximal acetylcholine (ACH) concentration M) showed a 42-87% greater release of amylase than tissues receiving ACH alone (p <0.001). The same potentiated response to ACH was seen in guinea pig pancreas pretreated with iso-OMPA (p <0.001), but iso-OMPA pretreatment did not augment the ACH response in the cat. Atropine pretreatment effectively blocked all ACH responses, and there was no effect seen with iso-OMPA alone. In the dog, iso-OMPA in combination with half-maximal carbachol (10−6M), or in combination with half-maximal cholecystokinin (CCK-8) stimulation (10−9M), provided no potentiated amylase release. BuChE is normally present in dog and guinea pig acinar cells, but is lacking in cat acinar cells. We conclude that OPs such as iso-OMPA cause a potentiated exocrine response to ACH in vitro and this effect can be satisfactorily explained by an anti-BuChE activity. Our results do not identify a mechanism relating the heightened cho linergic exocrine response to pancreatic toxicity." @default.
- W1995280565 created "2016-06-24" @default.
- W1995280565 creator A5013199591 @default.
- W1995280565 creator A5038986035 @default.
- W1995280565 creator A5054292368 @default.
- W1995280565 creator A5060323687 @default.
- W1995280565 creator A5071879800 @default.
- W1995280565 creator A5074176055 @default.
- W1995280565 date "1987-11-01" @default.
- W1995280565 modified "2023-09-25" @default.
- W1995280565 title "Effect of the Organophosphate iso-OMPA on Amylase Release by Pancreatic Lobules of Dog, Guinea Pig, and Cat" @default.
- W1995280565 doi "https://doi.org/10.1097/00006676-198711000-00007" @default.
- W1995280565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2449688" @default.
- W1995280565 hasPublicationYear "1987" @default.
- W1995280565 type Work @default.
- W1995280565 sameAs 1995280565 @default.
- W1995280565 citedByCount "5" @default.
- W1995280565 countsByYear W19952805652014 @default.
- W1995280565 countsByYear W19952805652022 @default.
- W1995280565 crossrefType "journal-article" @default.
- W1995280565 hasAuthorship W1995280565A5013199591 @default.
- W1995280565 hasAuthorship W1995280565A5038986035 @default.
- W1995280565 hasAuthorship W1995280565A5054292368 @default.
- W1995280565 hasAuthorship W1995280565A5060323687 @default.
- W1995280565 hasAuthorship W1995280565A5071879800 @default.
- W1995280565 hasAuthorship W1995280565A5074176055 @default.
- W1995280565 hasConcept C126322002 @default.
- W1995280565 hasConcept C134018914 @default.
- W1995280565 hasConcept C150903083 @default.
- W1995280565 hasConcept C161176658 @default.
- W1995280565 hasConcept C170493617 @default.
- W1995280565 hasConcept C170835558 @default.
- W1995280565 hasConcept C181199279 @default.
- W1995280565 hasConcept C185592680 @default.
- W1995280565 hasConcept C207001950 @default.
- W1995280565 hasConcept C22885893 @default.
- W1995280565 hasConcept C24998067 @default.
- W1995280565 hasConcept C2775859210 @default.
- W1995280565 hasConcept C2775910092 @default.
- W1995280565 hasConcept C2777593968 @default.
- W1995280565 hasConcept C2778815084 @default.
- W1995280565 hasConcept C2778988552 @default.
- W1995280565 hasConcept C2779842916 @default.
- W1995280565 hasConcept C55493867 @default.
- W1995280565 hasConcept C6557445 @default.
- W1995280565 hasConcept C71924100 @default.
- W1995280565 hasConcept C86803240 @default.
- W1995280565 hasConcept C98274493 @default.
- W1995280565 hasConceptScore W1995280565C126322002 @default.
- W1995280565 hasConceptScore W1995280565C134018914 @default.
- W1995280565 hasConceptScore W1995280565C150903083 @default.
- W1995280565 hasConceptScore W1995280565C161176658 @default.
- W1995280565 hasConceptScore W1995280565C170493617 @default.
- W1995280565 hasConceptScore W1995280565C170835558 @default.
- W1995280565 hasConceptScore W1995280565C181199279 @default.
- W1995280565 hasConceptScore W1995280565C185592680 @default.
- W1995280565 hasConceptScore W1995280565C207001950 @default.
- W1995280565 hasConceptScore W1995280565C22885893 @default.
- W1995280565 hasConceptScore W1995280565C24998067 @default.
- W1995280565 hasConceptScore W1995280565C2775859210 @default.
- W1995280565 hasConceptScore W1995280565C2775910092 @default.
- W1995280565 hasConceptScore W1995280565C2777593968 @default.
- W1995280565 hasConceptScore W1995280565C2778815084 @default.
- W1995280565 hasConceptScore W1995280565C2778988552 @default.
- W1995280565 hasConceptScore W1995280565C2779842916 @default.
- W1995280565 hasConceptScore W1995280565C55493867 @default.
- W1995280565 hasConceptScore W1995280565C6557445 @default.
- W1995280565 hasConceptScore W1995280565C71924100 @default.
- W1995280565 hasConceptScore W1995280565C86803240 @default.
- W1995280565 hasConceptScore W1995280565C98274493 @default.
- W1995280565 hasIssue "6" @default.
- W1995280565 hasLocation W19952805651 @default.
- W1995280565 hasLocation W19952805652 @default.
- W1995280565 hasOpenAccess W1995280565 @default.
- W1995280565 hasPrimaryLocation W19952805651 @default.
- W1995280565 hasRelatedWork W1972099714 @default.
- W1995280565 hasRelatedWork W1977702912 @default.
- W1995280565 hasRelatedWork W2039848084 @default.
- W1995280565 hasRelatedWork W2040046061 @default.
- W1995280565 hasRelatedWork W2046935652 @default.
- W1995280565 hasRelatedWork W2096288350 @default.
- W1995280565 hasRelatedWork W2130484943 @default.
- W1995280565 hasRelatedWork W2297949439 @default.
- W1995280565 hasRelatedWork W2410075499 @default.
- W1995280565 hasRelatedWork W3196736010 @default.
- W1995280565 hasVolume "2" @default.
- W1995280565 isParatext "false" @default.
- W1995280565 isRetracted "false" @default.
- W1995280565 magId "1995280565" @default.
- W1995280565 workType "article" @default.