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- W1995289044 abstract "The pathogenic fungus, Cryptococcus neoformans, is known to undergo phenotypic variation, which affects its virulence in the host. Recent investigations on C. neoformans cells in humans have validated the concept that phenotypic variation is present and relevant for the outcome of chronic cryptococcosis. The C. neoformans capsule is not the only trait that varies among strains. An emerging variant is the old cell phenotype generated when C. neoformans undergoes replicative aging. This phenotype, which other than larger size also exhibits a thickened cell wall, inhibits phagocytosis and killing by antifungals in vitro. In concert with the finding that old cells accumulate in vivo, this emergent trait could have significant impact on cryptococcal virulence and infection, and contribute to treatment failure." @default.
- W1995289044 created "2016-06-24" @default.
- W1995289044 creator A5012849145 @default.
- W1995289044 creator A5041693325 @default.
- W1995289044 date "2015-02-01" @default.
- W1995289044 modified "2023-09-30" @default.
- W1995289044 title "Aging: an emergent phenotypic trait that contributes to the virulence of <i>Cryptococcus neoformans</i>" @default.
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- W1995289044 doi "https://doi.org/10.2217/fmb.14.124" @default.
- W1995289044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4375546" @default.
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