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- W1995293206 abstract "Abstract Obesity is associated with colon carcinogenesis. However, not much information is available regarding the mechanisms of obesity‐associated colorectal cancer, and there are only few useful animal models for investigating the underlying mechanism between obesity and colorectal cancer. KK‐ A y mice exhibit severe obesity. Amount of visceral fat assessed by micro‐computed tomography was almost 15 times higher than that of same aged C57BL/6J mice. Treatment with azoxymethane (AOM; 200 μg/mouse injected once a week for 3 times) resulted in markedly increased colon aberrant crypt foci (ACF) development (≈70 ACF/mouse) in KK‐ A y mice compared with lean C57BL/6J mice (≈9 ACF/mouse). Moreover, administration of AOM at a dose of 200 μg/mouse once a week for 6 times developed colorectal adenocarcinomas within only 7 weeks after the last AOM injection. The incidence of adenocarcinoma was 88% in KK‐ A y mice and was markedly higher than the 4% observed in C57BL/6J mice. The number of tumors/mouse was 7.80 in KK‐ A y mice and also markedly higher than the 0.12 in the C57BL/6J case. Interestingly, adenocarcinomas were observed in most of the AOM‐treated KK‐ A y mice along with remarkable tumor angiogenesis, and some showed submucosal invasion. These results indicate that the KK‐ A y mouse, featuring intact leptin and leptin receptor Ob‐Rbl, could be a useful animal model to investigate obesity‐associated cancer." @default.
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- W1995293206 date "2010-11-23" @default.
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- W1995293206 title "High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice" @default.
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- W1995293206 doi "https://doi.org/10.1002/ijc.25711" @default.
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