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• W1995294737 abstract "Poxviruses encode a broad range of proteins that counteract the formidable attack of the immune response initiated in the host after infection, among which are proteins that mimic the extracellular binding domain of host cytokine receptors and are secreted from virus-infected cells. A soluble interferon-γ receptor (IFN-γR) is produced early after infection and efficiently blocks the binding of IFN-γ to cellular receptors, thus inhibiting both the anti-viral and immune functions of IFN-γ. An IFN-γR is highly conserved among members of the poxvirus family, suggesting a major role in viral pathogenesis. The highly species-specific nature of the IFN system enables questions concerning the evolutionary relationship between poxviruses and their hosts to be addressed. The IFN-γR encoded by myxoma virus, a natural pathogen of rabbits, is specific for rabbit IFN-γ. However, the IFN-γR encoded by orthopoxviruses (vaccinia, cowpox, camelpox, ectromelia) shows a novel, broad species specificity suggesting that these viruses have evolved in several species. The implications for the unknown origin and natural host(s) of vaccinia virus are discussed. Les Poxvirus suscitent l'apparition d'une grande quantité de protéines qui neutralise la formidable attaque de la résponse immune initiée chez l'hôte après l'infection. Parmi ces proteines, certaines imitent la partie extérieure des cytokines de l'hôtes et sont élaborées par le virus. Un récepteur soluble de l'interferon γ (IFN-γR) esi produit très tôt apres l'infection et bloque la liason récepteur cellulaire—IFN γ). Un IFR-γR est très présent parmi les membres de la famille des Pox, suggérant un rôle majeur dans la pathogènie virale. La spécificité du système de l'IFN autorise à se poser des questions concernant l'évolution des relations Pox-virus-hôtes. Le IFN-γR produit par le virus du myxome, virus pathogène pour le lapin, est spécifique de l'IFN γ. Cependant, l'IFN-γR produit pare les erthopoxvirus (vaccine, cowpos, camelpox, etromelie) montrent une spécificité d'espèce très large suggérnant que ces virus se sont développés dans plusieurs espèces. Les implications relativés à l'origine inconnue et aux hôtes naturels du virus de la vaccine sont discutées." @default.
• W1995294737 created "2016-06-24" @default.
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• W1995294737 date "1996-09-01" @default.
• W1995294737 modified "2023-09-26" @default.
• W1995294737 title "Soluble interferon-γ receptors encoded by poxviruses" @default.
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• W1995294737 doi "https://doi.org/10.1016/0147-9571(96)00013-6" @default.
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