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- W1995302249 abstract "Haptoglobin (Hp) is a glycoprotein that is produced by hepatic cells and secreted into the circulation. While studying the physiologic functions of Hp, we found that Hp synthesized in THP-1 monocytic cells was largely retained within cells, although Hp is considered a secretory protein. To investigate the molecular mechanism on Hp secretion in THP-1 cells, in the present study, we examined the effect of protein kinase C (PKC) on Hp secretion. When several inhibitors of PKC isoforms were tested, only Rottlerin, a specific inhibitor of PKC-delta, completely blocked Hp secretion from cells to culture medium. To confirm the role of PKC-delta in Hp secretion, Hp-overexpressing COS7 cells were transiently transfected with a wild-type or a dominantnegative mutant of the PKC-delta gene. Mutant PKC-delta significantly inhibited Hp secretion, whereas the wild-type gene slightly increased Hp secretion. These results demonstrate that the PKC-delta signal is involved in Hp secretion." @default.
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- W1995302249 date "2007-01-31" @default.
- W1995302249 modified "2023-09-24" @default.
- W1995302249 title "Protein Kinase C-delta Stimulates Haptoglobin Secretion" @default.
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- W1995302249 doi "https://doi.org/10.5483/bmbrep.2007.40.1.130" @default.
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