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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995305107> ?p ?o ?g. }

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• W1995305107 abstract "The ability of noncollagenous bone proteins (NCBP) to inhibit calcium phosphate precipitation in vitro raises the question as to the nature and the relative efficiency of such proteins in vivo. To investigate this question NCBP from young adult sheep bones were fractionated using nondegradative techniques. Their relative activity was measured by their efficiency in preventing hydroxyapatite growth. On a weight (of protein recovered) basis, the activity is about equally divided between the Gla-containing protein, osteocalcin, and a phosphorylated protein essentially the same as osteonectin. On a molecular weight basis, the activity of the phosphorylated protein is almost three times higher than that of the Gla-containing protein. Finally, the inhibitory activity of the phosphorylated protein is alkaline phosphatase sensitive. The properties of this protein could provide a means of regulating the solubility of bone mineral and maintaining an equilibrium of calcium between bone and blood. La capacité des protéines non collagéniques de l'os d'inhiber in vitro la précipitation du phosphate de calcium vient soulever la question de la nature et de l'efficacité relative de telles protéines in vivo. Pour étudier ce problèms, les protéines non collagéniques de l'os du jeune mouton adulte ont été fractionnées par des techniques évitant leur dégradation. Leur activité relative a été mesurée par leur efficacitéà réduire la croissance des cristaux d'hydroxyapatite. Sur la base du poids de protéines obtenues, l'activité est à peu près également répartie entre la Gla-protéine (ostéocalcine) et une protéine phosphorylée analogue à l'ostéonectine. D'après son poids moléculaire, l'activité de la protéine phosphorylée est Presque trois fois plus grande qua cells de la Gla-protéine. Enfin l'activité inhibitrice de la protéine phosphorylée est sensible à la phosphatase alcaline. Les propriétés de cette protéine devraient fournir les moyens de régulariser la solubilité du minéral osseux et de maintenir l'équilibre calcique entre l'os et le sang." @default.
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• W1995305107 date "1982-01-01" @default.
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• W1995305107 title "A study of bone proteins which can prevent hydroxyapatite formation" @default.
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• W1995305107 doi "https://doi.org/10.1016/0221-8747(82)90030-3" @default.
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