Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995307514> ?p ?o ?g. }
- W1995307514 endingPage "1139" @default.
- W1995307514 startingPage "1133" @default.
- W1995307514 abstract "We have shown that Fasciola hepatica expresses at least six β-tubulins in the adult stage of its life cycle, designated F.hep-β-tub1-6 (Ryan et al., 2008). Here we show that different complements of tubulin isotypes are expressed in different tissues and at different life cycle stages; this information may inform the search for novel anthelmintics. The predominant (as judged by quantitative PCR) isotype transcribed at the adult stage was F.hep-β-tub1 and immunolocalisation studies revealed that this isotype occurred mainly in mature spermatozoa and vitelline follicles. Quantitative PCR indicated that changes occurred in the transcription levels of β-tubulin isotypes at certain life cycle stages and may be of importance in the efficacy of benzimidazole-based anthelmintic drugs, but there were no significant differences between the triclabendazole-susceptible Leon isolate and the triclabendazole-resistant Oberon isolate in the transcription levels of each of the isotypes. When three well-characterised isolates with differing susceptibilities to triclabendazole were compared, only one amino acid change resulting from a homozygous coding sequence difference (Gly269Ser) in isotype 4 was observed. However, this change was not predicted to alter the overall structure of the protein. In conclusion, these findings indicate that there is tissue-specific expression of tubulin isotypes in the liver fluke but the development of resistance to triclabendazole is not associated with changes in its presumed target molecule." @default.
- W1995307514 created "2016-06-24" @default.
- W1995307514 creator A5007546946 @default.
- W1995307514 creator A5026973973 @default.
- W1995307514 creator A5036937827 @default.
- W1995307514 creator A5042133470 @default.
- W1995307514 creator A5042502461 @default.
- W1995307514 creator A5052154785 @default.
- W1995307514 creator A5056281445 @default.
- W1995307514 creator A5073134222 @default.
- W1995307514 creator A5076189270 @default.
- W1995307514 date "2013-12-01" @default.
- W1995307514 modified "2023-10-01" @default.
- W1995307514 title "Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages" @default.
- W1995307514 cites W1492449537 @default.
- W1995307514 cites W1500997013 @default.
- W1995307514 cites W1971693207 @default.
- W1995307514 cites W1980245995 @default.
- W1995307514 cites W1987306535 @default.
- W1995307514 cites W1987665281 @default.
- W1995307514 cites W1994345832 @default.
- W1995307514 cites W1995607214 @default.
- W1995307514 cites W2010702201 @default.
- W1995307514 cites W2011527577 @default.
- W1995307514 cites W2015100598 @default.
- W1995307514 cites W2028517805 @default.
- W1995307514 cites W2029065409 @default.
- W1995307514 cites W2031194201 @default.
- W1995307514 cites W2039614224 @default.
- W1995307514 cites W2040454615 @default.
- W1995307514 cites W2044047854 @default.
- W1995307514 cites W2053642730 @default.
- W1995307514 cites W2058997498 @default.
- W1995307514 cites W2060259273 @default.
- W1995307514 cites W2060290807 @default.
- W1995307514 cites W2064414856 @default.
- W1995307514 cites W2070516735 @default.
- W1995307514 cites W2072524334 @default.
- W1995307514 cites W2078083289 @default.
- W1995307514 cites W2081455193 @default.
- W1995307514 cites W2084523020 @default.
- W1995307514 cites W2088845955 @default.
- W1995307514 cites W2098428340 @default.
- W1995307514 cites W2108627006 @default.
- W1995307514 cites W2112044370 @default.
- W1995307514 cites W2118509035 @default.
- W1995307514 cites W2119795117 @default.
- W1995307514 cites W2124747558 @default.
- W1995307514 cites W2134575926 @default.
- W1995307514 cites W2140425945 @default.
- W1995307514 cites W2153492153 @default.
- W1995307514 cites W2161747928 @default.
- W1995307514 cites W2165543009 @default.
- W1995307514 cites W2322583738 @default.
- W1995307514 cites W2406987787 @default.
- W1995307514 doi "https://doi.org/10.1016/j.ijpara.2013.08.007" @default.
- W1995307514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24162076" @default.
- W1995307514 hasPublicationYear "2013" @default.
- W1995307514 type Work @default.
- W1995307514 sameAs 1995307514 @default.
- W1995307514 citedByCount "15" @default.
- W1995307514 countsByYear W19953075142014 @default.
- W1995307514 countsByYear W19953075142015 @default.
- W1995307514 countsByYear W19953075142016 @default.
- W1995307514 countsByYear W19953075142018 @default.
- W1995307514 countsByYear W19953075142020 @default.
- W1995307514 countsByYear W19953075142022 @default.
- W1995307514 countsByYear W19953075142023 @default.
- W1995307514 crossrefType "journal-article" @default.
- W1995307514 hasAuthorship W1995307514A5007546946 @default.
- W1995307514 hasAuthorship W1995307514A5026973973 @default.
- W1995307514 hasAuthorship W1995307514A5036937827 @default.
- W1995307514 hasAuthorship W1995307514A5042133470 @default.
- W1995307514 hasAuthorship W1995307514A5042502461 @default.
- W1995307514 hasAuthorship W1995307514A5052154785 @default.
- W1995307514 hasAuthorship W1995307514A5056281445 @default.
- W1995307514 hasAuthorship W1995307514A5073134222 @default.
- W1995307514 hasAuthorship W1995307514A5076189270 @default.
- W1995307514 hasConcept C138885662 @default.
- W1995307514 hasConcept C153911025 @default.
- W1995307514 hasConcept C159654299 @default.
- W1995307514 hasConcept C165901193 @default.
- W1995307514 hasConcept C179926584 @default.
- W1995307514 hasConcept C203014093 @default.
- W1995307514 hasConcept C20418707 @default.
- W1995307514 hasConcept C2776908094 @default.
- W1995307514 hasConcept C2777856171 @default.
- W1995307514 hasConcept C2777861111 @default.
- W1995307514 hasConcept C2777991845 @default.
- W1995307514 hasConcept C41895202 @default.
- W1995307514 hasConcept C542903549 @default.
- W1995307514 hasConcept C54355233 @default.
- W1995307514 hasConcept C84425145 @default.
- W1995307514 hasConcept C86803240 @default.
- W1995307514 hasConcept C90856448 @default.
- W1995307514 hasConceptScore W1995307514C138885662 @default.
- W1995307514 hasConceptScore W1995307514C153911025 @default.
- W1995307514 hasConceptScore W1995307514C159654299 @default.