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- W1995309969 abstract "In June 1976 a controlled randomized study was started on the usefulness of anticoagulant therapy in childhood hemolytic uremic syndrome.All infants and children with HUS,entering our department,are allocated to one of two different therapeutical schedules:the one consists of supportive therapy only (-ANT),the other comprises in addition the administration of heparin and dipyridamole (+ANT).Before dismissal,all patients undergo a percutaneous renal biopsy which is examined by light microscopy and immunofluorescence. Thirty-six patients have entered the study so far. Both groups are made of 18 infants and children and are almost similar as far as age distribution is concerned. The (+ANT)-group comprises an equal number of severe and mild cases whereas 12 children of the (-ANT)-group are considered to have had a mild form of the disease. Two children in the (+ANT)-group died, one of them three hours after admission, and one child in the (-ANT)-group,the overall mortality being 8.3%. Three patients in the (-ANT)-group had had an unusually prolonged course with severe hypertension, lasting for more than one year in one of them. All other patients made a reasonably quick recovery.A first analysis of the 34 kidney biopsies shows differences between both subgroups. These differences,although suggesting a beneficial effect of the anticoagulants,are,however,not statistically significant.Data on the long term evolution of kidney function are preliminary. Creatinine clearance values at 6, 12, 24 and 36 months are not statistically different between both groups." @default.
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- W1995309969 date "1980-08-01" @default.
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- W1995309969 title "ANTICOAGULANT THERAPY VERSUS NO SPECIFIC TREATMENT IN THE HEMOLYTIC UREMIC SYNDROME" @default.
- W1995309969 doi "https://doi.org/10.1203/00006450-198008000-00153" @default.
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