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• W1995315049 abstract "Purpose To investigate the effect of exogenous plasmin administration on the activity of endogenous matrix metalloproteinase-2 (MMP-2) in rabbit and human vitreous. Design Experimental animal study and interventional case series. Methods Human plasmin was injected into rabbit eyes. The active/pro-MMP-2 ratio in vitreous samples was calculated using the gelatin zymography. Scanning electron microscopy (SEM) was performed to observe the retinal surface. To evaluate the time course of MMP-2 activity, vitreous samples were collected after the injection of 0.5 IU of plasmin, and the active/pro-MMP-2 ratio was calculated in the same manner. Immunohistochemical analysis was performed to confirm the presence of MT1-MMP in the rabbit eye. Human vitreous samples obtained from vitreous surgeries were also used for similar studies. Results The active/pro-MMP-2 ratios in the vitreous after the injection of 0.25 IU or 0.5 IU of plasmin were significantly higher than that of the control (P < .05). SEM demonstrated that plasmin-treated eyes showed a smooth retinal surface that was dose-dependent. Time course evaluation of the active/pro-MMP-2 ratio in the vitreous after the administration of 0.5 IU of plasmin found a significant difference between the 5 and 15 minutes data points compared with that seen for the control. Immunohistochemical study revealed the presence of MT1-MMP in the inner retina. In human samples, the active/pro-MMP-2 ratio after the plasmin injection was significantly higher than the ratio observed before injection. Conclusions Our results suggested that activation of endogenous MMP-2 by exogenous plasmin is associated with the induction of posterior vitreous detachment. To investigate the effect of exogenous plasmin administration on the activity of endogenous matrix metalloproteinase-2 (MMP-2) in rabbit and human vitreous. Experimental animal study and interventional case series. Human plasmin was injected into rabbit eyes. The active/pro-MMP-2 ratio in vitreous samples was calculated using the gelatin zymography. Scanning electron microscopy (SEM) was performed to observe the retinal surface. To evaluate the time course of MMP-2 activity, vitreous samples were collected after the injection of 0.5 IU of plasmin, and the active/pro-MMP-2 ratio was calculated in the same manner. Immunohistochemical analysis was performed to confirm the presence of MT1-MMP in the rabbit eye. Human vitreous samples obtained from vitreous surgeries were also used for similar studies. The active/pro-MMP-2 ratios in the vitreous after the injection of 0.25 IU or 0.5 IU of plasmin were significantly higher than that of the control (P < .05). SEM demonstrated that plasmin-treated eyes showed a smooth retinal surface that was dose-dependent. Time course evaluation of the active/pro-MMP-2 ratio in the vitreous after the administration of 0.5 IU of plasmin found a significant difference between the 5 and 15 minutes data points compared with that seen for the control. Immunohistochemical study revealed the presence of MT1-MMP in the inner retina. In human samples, the active/pro-MMP-2 ratio after the plasmin injection was significantly higher than the ratio observed before injection. Our results suggested that activation of endogenous MMP-2 by exogenous plasmin is associated with the induction of posterior vitreous detachment." @default.
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• W1995315049 date "2005-10-01" @default.
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• W1995315049 title "Intravitreal Plasmin Injection Activates Endogenous Matrix Metalloproteinase-2 in Rabbit and Human Vitreous" @default.
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• W1995315049 doi "https://doi.org/10.1016/j.ajo.2005.04.017" @default.
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