Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995316524> ?p ?o ?g. }
- W1995316524 abstract "Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors, but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer and lung cancer. eEF1A1 modulates cytoskeleton, exhibits chaperone-like activity and also controls cell proliferation and cell death. By contrast eEF1A2 protein favors oncogenesis as shown by the fact that overexpression of eEF1A2 leads to cellular transformation and gives rise to tumors in nude mice. The eEF1A2 protein stimulates the phospholipid signaling and activates the Akt-dependent cell migration and actin remodeling that ultimately favors tumorigenesis. By contrast, inactivation of eEF1A proteins leads to immunodeficiency, neural and muscular defects, and favors apoptosis. Finally, eEF1A proteins interact with several viral proteins resulting in enhanced viral replication, decreased apoptosis and increased cellular transformation. This review summarizes the recent findings on eEF1A proteins indicating that eEF1A proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis and increased viral pathogenesis." @default.
- W1995316524 created "2016-06-24" @default.
- W1995316524 creator A5041439693 @default.
- W1995316524 creator A5043869216 @default.
- W1995316524 creator A5068727863 @default.
- W1995316524 date "2015-04-07" @default.
- W1995316524 modified "2023-10-11" @default.
- W1995316524 title "The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections" @default.
- W1995316524 cites W1488121527 @default.
- W1995316524 cites W1493871051 @default.
- W1995316524 cites W1503441328 @default.
- W1995316524 cites W1525867888 @default.
- W1995316524 cites W1560901632 @default.
- W1995316524 cites W1566421579 @default.
- W1995316524 cites W1569404236 @default.
- W1995316524 cites W1964246208 @default.
- W1995316524 cites W1965456554 @default.
- W1995316524 cites W1966167142 @default.
- W1995316524 cites W1967705712 @default.
- W1995316524 cites W1969404579 @default.
- W1995316524 cites W1969419767 @default.
- W1995316524 cites W1970242518 @default.
- W1995316524 cites W1970472201 @default.
- W1995316524 cites W1971637469 @default.
- W1995316524 cites W1974558715 @default.
- W1995316524 cites W1975008539 @default.
- W1995316524 cites W1975280406 @default.
- W1995316524 cites W1979538859 @default.
- W1995316524 cites W1980313235 @default.
- W1995316524 cites W1981786531 @default.
- W1995316524 cites W1984277720 @default.
- W1995316524 cites W1987945161 @default.
- W1995316524 cites W1992356221 @default.
- W1995316524 cites W1992848965 @default.
- W1995316524 cites W1994531005 @default.
- W1995316524 cites W2000269194 @default.
- W1995316524 cites W2002999352 @default.
- W1995316524 cites W2009826571 @default.
- W1995316524 cites W2010173857 @default.
- W1995316524 cites W2011826564 @default.
- W1995316524 cites W2013788352 @default.
- W1995316524 cites W2014002072 @default.
- W1995316524 cites W2014545259 @default.
- W1995316524 cites W2014746936 @default.
- W1995316524 cites W2015987550 @default.
- W1995316524 cites W2016756307 @default.
- W1995316524 cites W2019403342 @default.
- W1995316524 cites W2020352533 @default.
- W1995316524 cites W2020958484 @default.
- W1995316524 cites W2022228856 @default.
- W1995316524 cites W2022803736 @default.
- W1995316524 cites W2023706819 @default.
- W1995316524 cites W2024115521 @default.
- W1995316524 cites W2024544617 @default.
- W1995316524 cites W2026359346 @default.
- W1995316524 cites W2026659052 @default.
- W1995316524 cites W2028455351 @default.
- W1995316524 cites W2034694321 @default.
- W1995316524 cites W2035014104 @default.
- W1995316524 cites W2040935952 @default.
- W1995316524 cites W2041815339 @default.
- W1995316524 cites W2044378169 @default.
- W1995316524 cites W2045113803 @default.
- W1995316524 cites W2046760466 @default.
- W1995316524 cites W2049463158 @default.
- W1995316524 cites W2050762701 @default.
- W1995316524 cites W2052491502 @default.
- W1995316524 cites W2054056559 @default.
- W1995316524 cites W2056568168 @default.
- W1995316524 cites W2058681427 @default.
- W1995316524 cites W2060809301 @default.
- W1995316524 cites W2061842004 @default.
- W1995316524 cites W2065394512 @default.
- W1995316524 cites W2070962298 @default.
- W1995316524 cites W2071246036 @default.
- W1995316524 cites W2074481290 @default.
- W1995316524 cites W2075981998 @default.
- W1995316524 cites W2081749872 @default.
- W1995316524 cites W2082115514 @default.
- W1995316524 cites W2082276421 @default.
- W1995316524 cites W2086636612 @default.
- W1995316524 cites W2087132188 @default.
- W1995316524 cites W2088279551 @default.
- W1995316524 cites W2088629624 @default.
- W1995316524 cites W2090262794 @default.
- W1995316524 cites W2092809354 @default.
- W1995316524 cites W2095778156 @default.
- W1995316524 cites W2096547209 @default.
- W1995316524 cites W2100170686 @default.
- W1995316524 cites W2101537043 @default.
- W1995316524 cites W2101907683 @default.
- W1995316524 cites W2103214205 @default.
- W1995316524 cites W2105525143 @default.
- W1995316524 cites W2105587244 @default.
- W1995316524 cites W2107632648 @default.
- W1995316524 cites W2109902554 @default.
- W1995316524 cites W2113649068 @default.
- W1995316524 cites W2114956112 @default.
- W1995316524 cites W2115954319 @default.
- W1995316524 cites W2119977018 @default.