FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995322578> ?p ?o ?g. }

• W1995322578 endingPage "325" @default.
• W1995322578 startingPage "316" @default.
• W1995322578 abstract "Multicenter phase II trials with Gemtuzumab Ozogamicin (GO/Mylotarg), consisting of a CD33 antibody linked to the cytotoxic drug calicheamicin, have shown a 30% overall response rate in relapsed acute myeloid leukemia patients. However, no clear correlation was observed between CD33 expression on leukemic blasts and response to GO therapy. We analyzed the CD33 specificity of GO-induced cell death and the effect of GO on CD33-negative malignancies. We demonstrate that lysis induced by clinically relevant GO concentrations is partially CD33 mediated, and that efficient non-CD33-mediated GO uptake can occur via endocytosis. In agreement with these results, we observed GO-mediated death of human CD33-negative acute lymphoblastic leukemia cells both in vitro and in vivo in an NOD/SCID mouse model. Finally, sensitivity to GO-induced cell death was at least partially determined by the activation status of leukemic cells, with cells in activated phases of the cell cycle being most effective in both CD33-specific GO internalization, renewed expression of CD33 molecules, and non-CD33-mediated GO uptake via endocytosis. In conclusion, these data provide mechanistic insight into the efficacy of GO in CD33-positive as well as in CD33-negative malignancies with endocytic capacity, and provide a rationale for the use of GO in the treatment of malignancies with endocytic capacity." @default.
• W1995322578 created "2016-06-24" @default.
• W1995322578 creator A5006790084 @default.
• W1995322578 creator A5027341200 @default.
• W1995322578 creator A5046636501 @default.
• W1995322578 creator A5055745584 @default.
• W1995322578 creator A5080035300 @default.
• W1995322578 creator A5081186852 @default.
• W1995322578 creator A5089776151 @default.
• W1995322578 date "2003-11-13" @default.
• W1995322578 modified "2023-10-15" @default.
• W1995322578 title "Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity" @default.
• W1995322578 cites W1505327742 @default.
• W1995322578 cites W1767192282 @default.
• W1995322578 cites W183128447 @default.
• W1995322578 cites W1842764967 @default.
• W1995322578 cites W1983266647 @default.
• W1995322578 cites W1990138643 @default.
• W1995322578 cites W1991191438 @default.
• W1995322578 cites W2013051826 @default.
• W1995322578 cites W2026060974 @default.
• W1995322578 cites W2036479586 @default.
• W1995322578 cites W2039223287 @default.
• W1995322578 cites W2043873747 @default.
• W1995322578 cites W2076106584 @default.
• W1995322578 cites W2077248326 @default.
• W1995322578 cites W2084425535 @default.
• W1995322578 cites W2085047575 @default.
• W1995322578 cites W2089771537 @default.
• W1995322578 cites W2092788376 @default.
• W1995322578 cites W2137696432 @default.
• W1995322578 cites W2138388661 @default.
• W1995322578 cites W2148644851 @default.
• W1995322578 cites W2160835020 @default.
• W1995322578 cites W2326487196 @default.
• W1995322578 cites W2326561055 @default.
• W1995322578 cites W2344135414 @default.
• W1995322578 cites W3190509665 @default.
• W1995322578 cites W326932590 @default.
• W1995322578 cites W4235771239 @default.
• W1995322578 cites W4312790597 @default.
• W1995322578 cites W4385970358 @default.
• W1995322578 doi "https://doi.org/10.1038/sj.leu.2403205" @default.
• W1995322578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14614514" @default.
• W1995322578 hasPublicationYear "2003" @default.
• W1995322578 type Work @default.
• W1995322578 sameAs 1995322578 @default.
• W1995322578 citedByCount "124" @default.
• W1995322578 countsByYear W19953225782012 @default.
• W1995322578 countsByYear W19953225782013 @default.
• W1995322578 countsByYear W19953225782014 @default.
• W1995322578 countsByYear W19953225782015 @default.
• W1995322578 countsByYear W19953225782016 @default.
• W1995322578 countsByYear W19953225782017 @default.
• W1995322578 countsByYear W19953225782018 @default.
• W1995322578 countsByYear W19953225782019 @default.
• W1995322578 countsByYear W19953225782020 @default.
• W1995322578 countsByYear W19953225782021 @default.
• W1995322578 countsByYear W19953225782022 @default.
• W1995322578 countsByYear W19953225782023 @default.
• W1995322578 crossrefType "journal-article" @default.
• W1995322578 hasAuthorship W1995322578A5006790084 @default.
• W1995322578 hasAuthorship W1995322578A5027341200 @default.
• W1995322578 hasAuthorship W1995322578A5046636501 @default.
• W1995322578 hasAuthorship W1995322578A5055745584 @default.
• W1995322578 hasAuthorship W1995322578A5080035300 @default.
• W1995322578 hasAuthorship W1995322578A5081186852 @default.
• W1995322578 hasAuthorship W1995322578A5089776151 @default.
• W1995322578 hasBestOaLocation W19953225781 @default.
• W1995322578 hasConcept C10205521 @default.
• W1995322578 hasConcept C139770010 @default.
• W1995322578 hasConcept C1491633281 @default.
• W1995322578 hasConcept C176290653 @default.
• W1995322578 hasConcept C203014093 @default.
• W1995322578 hasConcept C2777701055 @default.
• W1995322578 hasConcept C2778245361 @default.
• W1995322578 hasConcept C2778623314 @default.
• W1995322578 hasConcept C2778729363 @default.
• W1995322578 hasConcept C28005876 @default.
• W1995322578 hasConcept C28328180 @default.
• W1995322578 hasConcept C502942594 @default.
• W1995322578 hasConcept C55493867 @default.
• W1995322578 hasConcept C79747257 @default.
• W1995322578 hasConcept C86803240 @default.
• W1995322578 hasConcept C8891405 @default.
• W1995322578 hasConcept C95444343 @default.
• W1995322578 hasConceptScore W1995322578C10205521 @default.
• W1995322578 hasConceptScore W1995322578C139770010 @default.
• W1995322578 hasConceptScore W1995322578C1491633281 @default.
• W1995322578 hasConceptScore W1995322578C176290653 @default.
• W1995322578 hasConceptScore W1995322578C203014093 @default.
• W1995322578 hasConceptScore W1995322578C2777701055 @default.
• W1995322578 hasConceptScore W1995322578C2778245361 @default.
• W1995322578 hasConceptScore W1995322578C2778623314 @default.
• W1995322578 hasConceptScore W1995322578C2778729363 @default.
• W1995322578 hasConceptScore W1995322578C28005876 @default.
• W1995322578 hasConceptScore W1995322578C28328180 @default.
• W1995322578 hasConceptScore W1995322578C502942594 @default.

• next