Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995331315> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1995331315 endingPage "528" @default.
- W1995331315 startingPage "515" @default.
- W1995331315 abstract "In pentobarbital-treated dogs clonidine (10 micrograms/kg) reduced the increase in heart rate caused by electrical stimulation of the cardiac nerve (1-10 Hz). We studied the actions of six alpha-adrenoceptor blocking drugs. Yohimbine (0.3 mg/kg) and phentolamine (1 mg/kg) potentiated the effects of nerve stimulation and antagonized the inhibitory effects of clonidine. Piperoxan (1 mg/kg) increased the response to nerve stimulation but antagonized the effects of clonidine only at the lowest frequency of stimulation. Thymoxamine (1 mg/kg) and prazosin at high doses (1 mg/kg) also antagonized the effects of clonidine but failed to increase the positive chronotropic response to stimulation of the cardiac nerve. AR-C239, a new and potent alpha-adrenoceptor blocking agent, changed neither the response to nerve stimulation nor the inhibitory effect of clonidine. The effects of all these drugs were observed at doses which reduced or reversed the pressor response to adrenaline. Therefore, our results afford further evidence for a dissimilarity between postsynaptic and presynaptic alpha-adrenoceptors in the dog. In addition, they show that the failure of an alpha-adrenoceptor blocking compound to increase the response to nerve stimulation does not necessarily indicate a lack of presynaptic alpha-adrenoceptor blockade." @default.
- W1995331315 created "2016-06-24" @default.
- W1995331315 creator A5007919371 @default.
- W1995331315 creator A5023843461 @default.
- W1995331315 creator A5032670304 @default.
- W1995331315 creator A5047814330 @default.
- W1995331315 creator A5082936059 @default.
- W1995331315 date "1979-09-01" @default.
- W1995331315 modified "2023-09-27" @default.
- W1995331315 title "Interactions Between Clonidine and α-Adrenoceptor Blocking Drugs on the Tachycardic Response to Stimulation of the Cardiac Nerve in Dogs" @default.
- W1995331315 doi "https://doi.org/10.1097/00005344-197909000-00004" @default.
- W1995331315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/94408" @default.
- W1995331315 hasPublicationYear "1979" @default.
- W1995331315 type Work @default.
- W1995331315 sameAs 1995331315 @default.
- W1995331315 citedByCount "10" @default.
- W1995331315 crossrefType "journal-article" @default.
- W1995331315 hasAuthorship W1995331315A5007919371 @default.
- W1995331315 hasAuthorship W1995331315A5023843461 @default.
- W1995331315 hasAuthorship W1995331315A5032670304 @default.
- W1995331315 hasAuthorship W1995331315A5047814330 @default.
- W1995331315 hasAuthorship W1995331315A5082936059 @default.
- W1995331315 hasBestOaLocation W19953313151 @default.
- W1995331315 hasConcept C126322002 @default.
- W1995331315 hasConcept C13348194 @default.
- W1995331315 hasConcept C134018914 @default.
- W1995331315 hasConcept C170493617 @default.
- W1995331315 hasConcept C17077164 @default.
- W1995331315 hasConcept C197341189 @default.
- W1995331315 hasConcept C24998067 @default.
- W1995331315 hasConcept C2776885963 @default.
- W1995331315 hasConcept C2777676773 @default.
- W1995331315 hasConcept C2778399450 @default.
- W1995331315 hasConcept C2778468042 @default.
- W1995331315 hasConcept C2780253649 @default.
- W1995331315 hasConcept C2780648677 @default.
- W1995331315 hasConcept C2780939551 @default.
- W1995331315 hasConcept C71924100 @default.
- W1995331315 hasConcept C98274493 @default.
- W1995331315 hasConceptScore W1995331315C126322002 @default.
- W1995331315 hasConceptScore W1995331315C13348194 @default.
- W1995331315 hasConceptScore W1995331315C134018914 @default.
- W1995331315 hasConceptScore W1995331315C170493617 @default.
- W1995331315 hasConceptScore W1995331315C17077164 @default.
- W1995331315 hasConceptScore W1995331315C197341189 @default.
- W1995331315 hasConceptScore W1995331315C24998067 @default.
- W1995331315 hasConceptScore W1995331315C2776885963 @default.
- W1995331315 hasConceptScore W1995331315C2777676773 @default.
- W1995331315 hasConceptScore W1995331315C2778399450 @default.
- W1995331315 hasConceptScore W1995331315C2778468042 @default.
- W1995331315 hasConceptScore W1995331315C2780253649 @default.
- W1995331315 hasConceptScore W1995331315C2780648677 @default.
- W1995331315 hasConceptScore W1995331315C2780939551 @default.
- W1995331315 hasConceptScore W1995331315C71924100 @default.
- W1995331315 hasConceptScore W1995331315C98274493 @default.
- W1995331315 hasIssue "5" @default.
- W1995331315 hasLocation W19953313151 @default.
- W1995331315 hasLocation W19953313152 @default.
- W1995331315 hasLocation W19953313153 @default.
- W1995331315 hasOpenAccess W1995331315 @default.
- W1995331315 hasPrimaryLocation W19953313151 @default.
- W1995331315 hasRelatedWork W1963869198 @default.
- W1995331315 hasRelatedWork W1995331315 @default.
- W1995331315 hasRelatedWork W2003313596 @default.
- W1995331315 hasRelatedWork W2003788231 @default.
- W1995331315 hasRelatedWork W2007426285 @default.
- W1995331315 hasRelatedWork W2033420892 @default.
- W1995331315 hasRelatedWork W2072143736 @default.
- W1995331315 hasRelatedWork W2094399653 @default.
- W1995331315 hasRelatedWork W2163156834 @default.
- W1995331315 hasRelatedWork W2409055232 @default.
- W1995331315 hasVolume "1" @default.
- W1995331315 isParatext "false" @default.
- W1995331315 isRetracted "false" @default.
- W1995331315 magId "1995331315" @default.
- W1995331315 workType "article" @default.