FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995340369> ?p ?o ?g. }

• W1995340369 endingPage "2012" @default.
• W1995340369 startingPage "2003" @default.
• W1995340369 abstract "The effects on thrombosis and hemostasis of thrombin-induced activation of endogenous protein C (PC) were evaluated in baboons. Thrombosis was induced by placing into arteriovenous shunts a segment of Dacron vascular graft, which generated arterial platelet-rich thrombus, followed by an expansion region of low-shear blood flow, which in turn accumulated fibrin-rich venous-type thrombus. Thrombosis was quantified by 111In-platelet imaging and 125I-fibrinogen accumulation. Intravenous infusion of alpha-thrombin, 1-2 U/kg-min for 1 h, increased baseline activated PC levels (approximately 5 ng/ml) to 250-500 ng/ml (P < 0.01). The lower thrombin dose, which did not deplete circulating platelets, fibrinogen, or PC, reduced arterial graft platelet deposition by 48% (P < 0.05), and platelet and fibrin incorporation into venous-type thrombus by > 85% (P < 0.01). Thrombin infusion prolonged the activated partial thromboplastin clotting time, elevated fibrinopeptide A (FPA), thrombin-antithrombin III complex (T:AT III), and fibrin D-dimer plasma levels (P < 0.01), but did not affect bleeding times. Thrombin's antithrombotic effects were blocked by infusing a monoclonal antibody (HPC-4) which prevented PC activation in vivo, caused shunt occlusion, increased the consumption of platelets and fibrinogen, elevated plasma FPA and T:AT III levels, and reduced factor VIII (but not factor V) procoagulant activity (P < 0.05). We conclude that activated PC is a physiologic inhibitor of thrombosis, and that activation of endogenous PC may represent a novel and effective antithrombotic strategy." @default.
• W1995340369 created "2016-06-24" @default.
• W1995340369 creator A5027011914 @default.
• W1995340369 creator A5036237322 @default.
• W1995340369 creator A5047037554 @default.
• W1995340369 creator A5056607779 @default.
• W1995340369 creator A5061652432 @default.
• W1995340369 creator A5065379380 @default.
• W1995340369 date "1993-10-01" @default.
• W1995340369 modified "2023-09-26" @default.
• W1995340369 title "Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates." @default.
• W1995340369 cites W1497151185 @default.
• W1995340369 cites W1497264889 @default.
• W1995340369 cites W1497924644 @default.
• W1995340369 cites W1512983489 @default.
• W1995340369 cites W1525413164 @default.
• W1995340369 cites W1554315814 @default.
• W1995340369 cites W1696947947 @default.
• W1995340369 cites W1908398222 @default.
• W1995340369 cites W1974458756 @default.
• W1995340369 cites W1975257619 @default.
• W1995340369 cites W1978559805 @default.
• W1995340369 cites W1981808231 @default.
• W1995340369 cites W1987360507 @default.
• W1995340369 cites W1995967510 @default.
• W1995340369 cites W1997597708 @default.
• W1995340369 cites W1999591312 @default.
• W1995340369 cites W2005959990 @default.
• W1995340369 cites W2009373062 @default.
• W1995340369 cites W2012915372 @default.
• W1995340369 cites W2015635746 @default.
• W1995340369 cites W2018235565 @default.
• W1995340369 cites W2023366837 @default.
• W1995340369 cites W2032711004 @default.
• W1995340369 cites W2036952672 @default.
• W1995340369 cites W2038058775 @default.
• W1995340369 cites W2038681046 @default.
• W1995340369 cites W2042168975 @default.
• W1995340369 cites W2042935486 @default.
• W1995340369 cites W2046204460 @default.
• W1995340369 cites W2058112726 @default.
• W1995340369 cites W2074044112 @default.
• W1995340369 cites W2075331103 @default.
• W1995340369 cites W2079487514 @default.
• W1995340369 cites W2084127915 @default.
• W1995340369 cites W2085445739 @default.
• W1995340369 cites W2097908856 @default.
• W1995340369 cites W2112348962 @default.
• W1995340369 cites W2114963157 @default.
• W1995340369 cites W2137699511 @default.
• W1995340369 cites W2152303123 @default.
• W1995340369 cites W2162724050 @default.
• W1995340369 cites W2282171044 @default.
• W1995340369 cites W2382154612 @default.
• W1995340369 cites W2394753640 @default.
• W1995340369 cites W2401139466 @default.
• W1995340369 cites W2404848933 @default.
• W1995340369 cites W2407948620 @default.
• W1995340369 cites W2408598201 @default.
• W1995340369 cites W2414396290 @default.
• W1995340369 cites W2414783014 @default.
• W1995340369 cites W2418305903 @default.
• W1995340369 cites W2418353908 @default.
• W1995340369 cites W2440566021 @default.
• W1995340369 cites W2443255991 @default.
• W1995340369 cites W321836716 @default.
• W1995340369 cites W62994428 @default.
• W1995340369 cites W90676001 @default.
• W1995340369 doi "https://doi.org/10.1172/jci116795" @default.
• W1995340369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/288368" @default.
• W1995340369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8408654" @default.
• W1995340369 hasPublicationYear "1993" @default.
• W1995340369 type Work @default.
• W1995340369 sameAs 1995340369 @default.
• W1995340369 citedByCount "170" @default.
• W1995340369 countsByYear W19953403692012 @default.
• W1995340369 countsByYear W19953403692013 @default.
• W1995340369 countsByYear W19953403692015 @default.
• W1995340369 countsByYear W19953403692016 @default.
• W1995340369 countsByYear W19953403692017 @default.
• W1995340369 countsByYear W19953403692018 @default.
• W1995340369 countsByYear W19953403692019 @default.
• W1995340369 countsByYear W19953403692020 @default.
• W1995340369 countsByYear W19953403692021 @default.
• W1995340369 crossrefType "journal-article" @default.
• W1995340369 hasAuthorship W1995340369A5027011914 @default.
• W1995340369 hasAuthorship W1995340369A5036237322 @default.
• W1995340369 hasAuthorship W1995340369A5047037554 @default.
• W1995340369 hasAuthorship W1995340369A5056607779 @default.
• W1995340369 hasAuthorship W1995340369A5061652432 @default.
• W1995340369 hasAuthorship W1995340369A5065379380 @default.
• W1995340369 hasBestOaLocation W19953403691 @default.
• W1995340369 hasConcept C126322002 @default.
• W1995340369 hasConcept C185592680 @default.
• W1995340369 hasConcept C186738567 @default.
• W1995340369 hasConcept C203014093 @default.
• W1995340369 hasConcept C2777292125 @default.
• W1995340369 hasConcept C2778261982 @default.

• next