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- W1995352925 abstract "In a context where injection of antigen (Ag)-specific T cells probably represents the future of leukemia immunotherapy, identification of optimal target Ags is crucial. We therefore sought to discover a reliable marker for selection of the most potent Ags. To this end, (1) we immunized mice against 8 individual Ags: 4 minor histocompatibility Ags (miHAs) and 4 leukemia-associated Ags (LAAs) that were overexpressed on leukemic relative to normal thymocytes; (2) we assessed their ability to reject EL4 leukemic cells; and (3) we correlated the properties of our Ags (and their cognate T cells) with their ability to induce protective antileukemic responses. Overall, individual miHAs instigated more potent antileukemic responses than LAAs. Three features had no influence on the ability of primed T cells to reject leukemic cells: (1) MHC-peptide affinity; (2) the stability of MHC-peptide complexes; and (3) epitope density at the surface of leukemic cells, as assessed using mass spectrometry. The cardinal feature of successful Ags is that they were recognized by high-avidity CD8 T cells that proliferated extensively in vivo. Our work suggests that in vitro evaluation of functional avidity represents the best criterion for selection of Ags, which should be prioritized in clinical trials of leukemia immunotherapy." @default.
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- W1995352925 date "2014-01-01" @default.
- W1995352925 modified "2023-10-03" @default.
- W1995352925 title "Rejection of Leukemic Cells Requires Antigen-Specific T Cells with High Functional Avidity" @default.
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- W1995352925 doi "https://doi.org/10.1016/j.bbmt.2013.10.020" @default.
- W1995352925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24161924" @default.
- W1995352925 hasPublicationYear "2014" @default.
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