FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995355143> ?p ?o ?g. }

• W1995355143 endingPage "735" @default.
• W1995355143 startingPage "725" @default.
• W1995355143 abstract "Tumor necrosis factor (TNF) is a multipotential cytokine that induces apoptosis and activates nuclear factor-kappa B (NF-kappaB), activation protein 1 (AP-1), mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK). Several mechanisms have been suggested to explain these effects of TNF, one of them being the involvement of reactive oxygen intermediates (ROI). Because Bcl-2 family members are known to affect the redox status of the cell, we examined the effect of Bcl-x(L) expression on TNF signaling. Overexpression of Bcl-x(L) in human promyelocytic lymphoma HL-60 cells downregulated TNF-induced cytotoxicity. Cleavage of poly (ADP-ribose) polymerase by caspases, an early indicator of apoptosis, was also blocked by Bcl-x(L) overexpression. Activation of NF-kappaB was significantly suppressed in cells overexpressing Bcl-x(L), as was degradation of IkappaBalpha, the inhibitory subunit of NF-kappaB. NF-kappaB activation induced by serum-activated lipopolysaccharide (SALPS), ceramide, and okadaic acid was also inhibited by overexpression of Bcl-x(L), whereas that by phorbol myristate acetate (PMA) and H2O2 was unaffected. Besides NF-kappaB, the activation of AP-1 by TNF also was blocked by Bcl-x(L). The activation of JNK and MAPK kinase, which regulate these transcription factors, was reduced in Bcl-x(L)-transfected cells. Overall, our results demonstrate that Bcl-x(L) inhibits TNF signaling at an early step common to induction of activation of apoptosis, NF-kappaB, AP-1, MAPK, and JNK." @default.
• W1995355143 created "2016-06-24" @default.
• W1995355143 creator A5009525500 @default.
• W1995355143 creator A5031631094 @default.
• W1995355143 creator A5048675624 @default.
• W1995355143 date "2000-08-01" @default.
• W1995355143 modified "2023-10-15" @default.
• W1995355143 title "Bcl-x_LSuppresses TNF-Mediated Apoptosis and Activation of Nuclear Factor-κB, Activation Protein-1, and c-Jun N-Terminal Kinase" @default.
• W1995355143 cites W1486894501 @default.
• W1995355143 cites W1500857509 @default.
• W1995355143 cites W1502098090 @default.
• W1995355143 cites W1517251498 @default.
• W1995355143 cites W1541329328 @default.
• W1995355143 cites W1577403013 @default.
• W1995355143 cites W1825703274 @default.
• W1995355143 cites W1889946000 @default.
• W1995355143 cites W1964390988 @default.
• W1995355143 cites W1969158591 @default.
• W1995355143 cites W1970480006 @default.
• W1995355143 cites W1973060929 @default.
• W1995355143 cites W1975356481 @default.
• W1995355143 cites W1976226379 @default.
• W1995355143 cites W1976385326 @default.
• W1995355143 cites W1979995768 @default.
• W1995355143 cites W1984113136 @default.
• W1995355143 cites W1984874586 @default.
• W1995355143 cites W1987848849 @default.
• W1995355143 cites W1993170284 @default.
• W1995355143 cites W1996180957 @default.
• W1995355143 cites W1997208169 @default.
• W1995355143 cites W2015773346 @default.
• W1995355143 cites W2016730049 @default.
• W1995355143 cites W2017973051 @default.
• W1995355143 cites W2026296367 @default.
• W1995355143 cites W2026299299 @default.
• W1995355143 cites W2036224418 @default.
• W1995355143 cites W2037283275 @default.
• W1995355143 cites W2037473273 @default.
• W1995355143 cites W2040125444 @default.
• W1995355143 cites W2040470926 @default.
• W1995355143 cites W2040852036 @default.
• W1995355143 cites W2053102794 @default.
• W1995355143 cites W2054526986 @default.
• W1995355143 cites W2056469110 @default.
• W1995355143 cites W2063176993 @default.
• W1995355143 cites W2067239197 @default.
• W1995355143 cites W2076807689 @default.
• W1995355143 cites W2114265064 @default.
• W1995355143 cites W2118897660 @default.
• W1995355143 cites W2122017693 @default.
• W1995355143 cites W2124418207 @default.
• W1995355143 cites W2135753091 @default.
• W1995355143 doi "https://doi.org/10.1089/10799900050116435" @default.
• W1995355143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10954916" @default.
• W1995355143 hasPublicationYear "2000" @default.
• W1995355143 type Work @default.
• W1995355143 sameAs 1995355143 @default.
• W1995355143 citedByCount "20" @default.
• W1995355143 countsByYear W19953551432013 @default.
• W1995355143 countsByYear W19953551432015 @default.
• W1995355143 crossrefType "journal-article" @default.
• W1995355143 hasAuthorship W1995355143A5009525500 @default.
• W1995355143 hasAuthorship W1995355143A5031631094 @default.
• W1995355143 hasAuthorship W1995355143A5048675624 @default.
• W1995355143 hasConcept C104317684 @default.
• W1995355143 hasConcept C134018914 @default.
• W1995355143 hasConcept C153911025 @default.
• W1995355143 hasConcept C17991360 @default.
• W1995355143 hasConcept C184235292 @default.
• W1995355143 hasConcept C185592680 @default.
• W1995355143 hasConcept C190283241 @default.
• W1995355143 hasConcept C2779087070 @default.
• W1995355143 hasConcept C55493867 @default.
• W1995355143 hasConcept C57074206 @default.
• W1995355143 hasConcept C62478195 @default.
• W1995355143 hasConcept C86339819 @default.
• W1995355143 hasConcept C86803240 @default.
• W1995355143 hasConcept C95444343 @default.
• W1995355143 hasConcept C97029542 @default.
• W1995355143 hasConceptScore W1995355143C104317684 @default.
• W1995355143 hasConceptScore W1995355143C134018914 @default.
• W1995355143 hasConceptScore W1995355143C153911025 @default.
• W1995355143 hasConceptScore W1995355143C17991360 @default.
• W1995355143 hasConceptScore W1995355143C184235292 @default.
• W1995355143 hasConceptScore W1995355143C185592680 @default.
• W1995355143 hasConceptScore W1995355143C190283241 @default.
• W1995355143 hasConceptScore W1995355143C2779087070 @default.
• W1995355143 hasConceptScore W1995355143C55493867 @default.
• W1995355143 hasConceptScore W1995355143C57074206 @default.
• W1995355143 hasConceptScore W1995355143C62478195 @default.
• W1995355143 hasConceptScore W1995355143C86339819 @default.
• W1995355143 hasConceptScore W1995355143C86803240 @default.
• W1995355143 hasConceptScore W1995355143C95444343 @default.
• W1995355143 hasConceptScore W1995355143C97029542 @default.
• W1995355143 hasIssue "8" @default.
• W1995355143 hasLocation W19953551431 @default.
• W1995355143 hasLocation W19953551432 @default.
• W1995355143 hasOpenAccess W1995355143 @default.

• next