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• W1995355260 abstract "Ischemic/reperfusion (I/R) injury of the spinal cord is a serious complication that can result from thoracoabdominal aortic surgery.To investigate the neuroprotective effect of curcumin against I/R injury in a rabbit model.A total of 36 rabbits were randomly divided into three groups: sham, I/R, and curcumin-treated group. Rabbits were subject to 30-min aortic occlusion to induce transient spinal cord ischemia. Neurological function was observed after reperfusion and spinal cord segment (L3-L5) was collected for histopathological evaluation. Malondialdehyde (MDA) and total superoxide dismutase (SOD) activity were also assayed.Rabbits in I/R group were induced to paraplegia. While after 48-hour treatment, compared with I/R group, curcumin significantly improved neurological function, reduced cell apoptosis and MDA levels as well as increased SOD activity (P < 0.05).The results suggest that curcumin, at least in an animal model, can attenuate transient spinal cord ischemic injury potentially via reducing oxidative damage, which may provide a novel approach in the treatment of spinal cord ischemic injury." @default.
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• W1995355260 date "2013-03-01" @default.
• W1995355260 modified "2023-09-25" @default.
• W1995355260 title "Neuroprotective effect of curcumin on spinal cord in rabbit model with ischemia/reperfusion" @default.
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• W1995355260 doi "https://doi.org/10.1179/2045772312y.0000000028" @default.
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