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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995355657> ?p ?o ?g. }

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• W1995355657 abstract "In two patients with fatal Reye's Syndrome, total ornithine carbamoyltransferase (OCTase) activity in the liver was 50 and 75% of that found in three control livers. The levels of enzymatic activity would not be expected to have resulted in the 7- and 17-fold elevations in plasma ammonia levels found in the patients. Levels of 47 and 60% of the OCTase activity, however, were found in the cytosolic fraction compared to an average of 7% for control livers. Thus, the amount of enzymatic activity in the mitochondrial fractions was only 20 and 30% of that found in control mitochondrial fractions. This study suggests that, if only mitochondrial OCTase is active in the urea cycle, the decreases in functional enzyme found in Reye's Syndrome may be considerably greater than that reflected in total enzyme assays." @default.
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• W1995355657 date "1991-10-01" @default.
• W1995355657 modified "2023-10-16" @default.
• W1995355657 title "Displacement of hepatic ornithine carbamoyltransferase from mitochondria to cytosol in Reye's Syndrome" @default.
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• W1995355657 doi "https://doi.org/10.1016/0885-4505(91)90073-t" @default.
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