FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995360570> ?p ?o ?g. }

• W1995360570 endingPage "e81411" @default.
• W1995360570 startingPage "e81411" @default.
• W1995360570 abstract "Benign prostatic hyperplasia (BPH) represents a pattern of non-malignant growth of prostatic fibromuscular stroma. Metabolic disturbances such us pre-diabetes and metabolic syndrome may have a role in BPH pathophysiology. A potential explanation for the above relationship involves the insulin-like growth factor (IGF) axis as well as IGF binding proteins, (IGFBPs) of which the most abundant form is IGFBP-3. Therefore, the aim of the present study was to investigate the association between intra-prostatic levels of IGF-1, IGF-2 as well as to evaluate the role of locally expressed IGFBP-3 in BPH development in pre-diabetes. A total of 49 patients admitted to the Urology department of a tertiary urban Greek hospital, for transurethral prostate resection, or prostatectomy and with pre-diabetes [impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) or both] were finally included. The majority of the sample consisted of subjects with IGT (51.0%), followed by IFG and IGT (32.7%) and isolated IFG (16.3%). For all participants a clinical examination was performed and blood samples were collected. In addition, total prostate (TP) volume or transitional zone (TZ) volume were estimated by transrectal ultrasonography. The results of the multivariate analysis regarding TP volume showed that higher PSA (p<0.001), larger waist circumference (p=0.007) and higher IGFBP-3 expression levels (p<0.001) independently predicted higher TP volume. The results regarding the volume of the TZ showed that higher PSA (p<0.001), larger waist circumference (p<0.001) and higher IGFBP-3 expression levels (p=0.024) were independently associated with higher TZ volume. Our findings show that intra-prostatic levels of IGFBP-3, PSA and waist circumference, but not overall obesity, are positively associated with prostate volume. IGFBP-3 seems to be a multifunctional protein, which can potentiate or inhibit IGF activity." @default.
• W1995360570 created "2016-06-24" @default.
• W1995360570 creator A5006991083 @default.
• W1995360570 creator A5009189085 @default.
• W1995360570 creator A5019160213 @default.
• W1995360570 creator A5031136439 @default.
• W1995360570 creator A5036320085 @default.
• W1995360570 creator A5049423288 @default.
• W1995360570 creator A5052358125 @default.
• W1995360570 creator A5053400450 @default.
• W1995360570 creator A5081272181 @default.
• W1995360570 date "2013-12-19" @default.
• W1995360570 modified "2023-09-27" @default.
• W1995360570 title "Linking Pre-Diabetes with Benign Prostate Hyperplasia. IGFBP-3: A Conductor of Benign Prostate Hyperplasia Development Orchestra?" @default.
• W1995360570 cites W14779780 @default.
• W1995360570 cites W169941286 @default.
• W1995360570 cites W1902678347 @default.
• W1995360570 cites W1932926379 @default.
• W1995360570 cites W1950253279 @default.
• W1995360570 cites W1967664341 @default.
• W1995360570 cites W1968766654 @default.
• W1995360570 cites W1970373365 @default.
• W1995360570 cites W1976951020 @default.
• W1995360570 cites W1980613758 @default.
• W1995360570 cites W1989440602 @default.
• W1995360570 cites W1990355823 @default.
• W1995360570 cites W1993194661 @default.
• W1995360570 cites W1994043247 @default.
• W1995360570 cites W1996005560 @default.
• W1995360570 cites W1999158243 @default.
• W1995360570 cites W2005527990 @default.
• W1995360570 cites W2007228548 @default.
• W1995360570 cites W2012150165 @default.
• W1995360570 cites W2014418366 @default.
• W1995360570 cites W2016557888 @default.
• W1995360570 cites W2020267609 @default.
• W1995360570 cites W2027066393 @default.
• W1995360570 cites W2031169955 @default.
• W1995360570 cites W2039060355 @default.
• W1995360570 cites W2045504344 @default.
• W1995360570 cites W2045918150 @default.
• W1995360570 cites W2048734658 @default.
• W1995360570 cites W2063049842 @default.
• W1995360570 cites W2064819768 @default.
• W1995360570 cites W2065022828 @default.
• W1995360570 cites W2069605381 @default.
• W1995360570 cites W2072114519 @default.
• W1995360570 cites W2081474553 @default.
• W1995360570 cites W2085238920 @default.
• W1995360570 cites W2085812784 @default.
• W1995360570 cites W2094926124 @default.
• W1995360570 cites W2100467144 @default.
• W1995360570 cites W2111140097 @default.
• W1995360570 cites W2115303137 @default.
• W1995360570 cites W2118915801 @default.
• W1995360570 cites W2119666243 @default.
• W1995360570 cites W2124143789 @default.
• W1995360570 cites W2124953624 @default.
• W1995360570 cites W2126443064 @default.
• W1995360570 cites W2127187614 @default.
• W1995360570 cites W2131136365 @default.
• W1995360570 cites W2131257484 @default.
• W1995360570 cites W2131627141 @default.
• W1995360570 cites W2131937256 @default.
• W1995360570 cites W2134886965 @default.
• W1995360570 cites W2135233886 @default.
• W1995360570 cites W2137831939 @default.
• W1995360570 cites W2141569406 @default.
• W1995360570 cites W2146281387 @default.
• W1995360570 cites W2151412408 @default.
• W1995360570 cites W2154108370 @default.
• W1995360570 cites W2156982018 @default.
• W1995360570 cites W2164113696 @default.
• W1995360570 cites W2170321998 @default.
• W1995360570 cites W2322310628 @default.
• W1995360570 cites W2416107013 @default.
• W1995360570 cites W3027446665 @default.
• W1995360570 doi "https://doi.org/10.1371/journal.pone.0081411" @default.
• W1995360570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3868595" @default.
• W1995360570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24367483" @default.
• W1995360570 hasPublicationYear "2013" @default.
• W1995360570 type Work @default.
• W1995360570 sameAs 1995360570 @default.
• W1995360570 citedByCount "4" @default.
• W1995360570 countsByYear W19953605702015 @default.
• W1995360570 countsByYear W19953605702020 @default.
• W1995360570 countsByYear W19953605702022 @default.
• W1995360570 crossrefType "journal-article" @default.
• W1995360570 hasAuthorship W1995360570A5006991083 @default.
• W1995360570 hasAuthorship W1995360570A5009189085 @default.
• W1995360570 hasAuthorship W1995360570A5019160213 @default.
• W1995360570 hasAuthorship W1995360570A5031136439 @default.
• W1995360570 hasAuthorship W1995360570A5036320085 @default.
• W1995360570 hasAuthorship W1995360570A5049423288 @default.
• W1995360570 hasAuthorship W1995360570A5052358125 @default.
• W1995360570 hasAuthorship W1995360570A5053400450 @default.
• W1995360570 hasAuthorship W1995360570A5081272181 @default.
• W1995360570 hasBestOaLocation W19953605701 @default.

• next