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- W1995367785 abstract "The X-ray structure of the photoreceptor rhodopsin has provided the first atomic-resolution structure of a seven-transmembrane (7-TM) G-protein-coupled receptor. This has provided an improved template for interpreting the huge body of structure--activity, mutagenesis and affinity labelling data available for related 7-TM receptors, such as muscarinic acetylcholine receptors. Ligand contacts, and the intramolecular interactions that stabilize the ground state structure, can be identified with some degree of confidence. We now have a firm basis for attempts to predict the structure of the receptor--G-protein complex, and understand the mechanism by which the agonist--receptor complex activates the G protein." @default.
- W1995367785 created "2016-06-24" @default.
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- W1995367785 creator A5056182419 @default.
- W1995367785 creator A5068176108 @default.
- W1995367785 date "2002-03-01" @default.
- W1995367785 modified "2023-10-17" @default.
- W1995367785 title "Seven-transmembrane receptors: crystals clarify" @default.
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- W1995367785 doi "https://doi.org/10.1016/s0165-6147(00)01973-8" @default.
- W1995367785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11879682" @default.
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