Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995371118> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1995371118 abstract "Basal hypothalamic deafferentation extending from the posterior border of the optic chiasm to the mid-mammillary bodies resulted in depression of plasma TSH, thyroxine (T4), and triiodothyronine (T3) concentration to 50% of normal controls within 7 days. Administration of 0.15% propylthiouracil (PTU) in the diet form postoperative day 26 caused a pronounced drop in the plasma T3 level and a rise in plasma TSH level within two days in the control animals, but had little effect during this interval in the deafferented animals. After 12 days of PTU, plasma T3 and T4 concentrations had dropped to undetectable concentrations in the control animals but both were still detectable in the deafferented animals. After 25 days of PTU, plasms T4 and T3 levels were undetectable and plasma TSH levels were significantly elevated above normal in all animals. Thyroid hypertrophy at that time was as great in the deafferented as in the control rats, although plasma TSH concentration was 50% lower in the former. Administration of 0.1 mug/100 g BW TRH iv on postoperative day 37, when plasma T4 and T3 were undetectable in the controls but still present in the deafferented animals, produced an equally high concentration of plasma TSH in all animals. We interpret these data to support the concepts that: 1) a major source of neural drive of that TRH which stimulates the secretion of TSH by the adenohypophysis lies outside the medial basal hypothalamus, 2) a decrease in TRH reaching the adenohypophysis causes a lower setting of the thyrostat sensitive to the concentration of circulating thyroid hormone, and 3) increased TSH secretion and resultant goitrogenesis is delayed in animals with impaired TRH secretion because of the slower rate of secretion of thyroid hormone than in intact controls and the longer time thus required to markedly reduce the concentration of circulating thyroid hormone." @default.
- W1995371118 created "2016-06-24" @default.
- W1995371118 creator A5026423669 @default.
- W1995371118 creator A5073178915 @default.
- W1995371118 date "1977-04-01" @default.
- W1995371118 modified "2023-10-14" @default.
- W1995371118 title "The Effect of Basal Hypothalamic Isolation on Pituitary-Thyroid Activity and the Response to Propylthiouracil" @default.
- W1995371118 cites W1989314580 @default.
- W1995371118 doi "https://doi.org/10.1210/endo-100-4-911" @default.
- W1995371118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/402261" @default.
- W1995371118 hasPublicationYear "1977" @default.
- W1995371118 type Work @default.
- W1995371118 sameAs 1995371118 @default.
- W1995371118 citedByCount "22" @default.
- W1995371118 countsByYear W19953711182016 @default.
- W1995371118 crossrefType "journal-article" @default.
- W1995371118 hasAuthorship W1995371118A5026423669 @default.
- W1995371118 hasAuthorship W1995371118A5073178915 @default.
- W1995371118 hasConcept C126322002 @default.
- W1995371118 hasConcept C134018914 @default.
- W1995371118 hasConcept C185592680 @default.
- W1995371118 hasConcept C2775960720 @default.
- W1995371118 hasConcept C2777003273 @default.
- W1995371118 hasConcept C2777195454 @default.
- W1995371118 hasConcept C2777658017 @default.
- W1995371118 hasConcept C2778024521 @default.
- W1995371118 hasConcept C2778288131 @default.
- W1995371118 hasConcept C2779306644 @default.
- W1995371118 hasConcept C526584372 @default.
- W1995371118 hasConcept C71315377 @default.
- W1995371118 hasConcept C71924100 @default.
- W1995371118 hasConceptScore W1995371118C126322002 @default.
- W1995371118 hasConceptScore W1995371118C134018914 @default.
- W1995371118 hasConceptScore W1995371118C185592680 @default.
- W1995371118 hasConceptScore W1995371118C2775960720 @default.
- W1995371118 hasConceptScore W1995371118C2777003273 @default.
- W1995371118 hasConceptScore W1995371118C2777195454 @default.
- W1995371118 hasConceptScore W1995371118C2777658017 @default.
- W1995371118 hasConceptScore W1995371118C2778024521 @default.
- W1995371118 hasConceptScore W1995371118C2778288131 @default.
- W1995371118 hasConceptScore W1995371118C2779306644 @default.
- W1995371118 hasConceptScore W1995371118C526584372 @default.
- W1995371118 hasConceptScore W1995371118C71315377 @default.
- W1995371118 hasConceptScore W1995371118C71924100 @default.
- W1995371118 hasLocation W19953711181 @default.
- W1995371118 hasLocation W19953711182 @default.
- W1995371118 hasOpenAccess W1995371118 @default.
- W1995371118 hasPrimaryLocation W19953711181 @default.
- W1995371118 hasRelatedWork W1966831514 @default.
- W1995371118 hasRelatedWork W1986172466 @default.
- W1995371118 hasRelatedWork W1995371118 @default.
- W1995371118 hasRelatedWork W1999436465 @default.
- W1995371118 hasRelatedWork W2005643801 @default.
- W1995371118 hasRelatedWork W2071388556 @default.
- W1995371118 hasRelatedWork W2099882901 @default.
- W1995371118 hasRelatedWork W2106664880 @default.
- W1995371118 hasRelatedWork W2131377884 @default.
- W1995371118 hasRelatedWork W2417887763 @default.
- W1995371118 isParatext "false" @default.
- W1995371118 isRetracted "false" @default.
- W1995371118 magId "1995371118" @default.
- W1995371118 workType "article" @default.