FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995373608> ?p ?o ?g. }

• W1995373608 endingPage "3640" @default.
• W1995373608 startingPage "3624" @default.
• W1995373608 abstract "In the last two decades the field of infrared spectroscopy has seen enormous advances in both instrumentation and the development of bioinformatic methods for spectral analysis, allowing the examination of a large variety of healthy and diseased samples, including biological fluids, isolated cells, whole tissues, and tissue sections. The non-destructive nature of the technique, together with the ability to directly probe biochemical changes without the addition of stains or contrast agents, enables a range of complementary analyses. This review focuses on the application of Fourier transform infrared (FTIR) microspectroscopy to analyse central nervous system tissues, with the aim of understanding the biochemical and structural changes associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, transmissible spongiform encephalopathies, multiple sclerosis, as well as brain tumours. Modern biospectroscopic methods that combine FTIR microspectroscopy with bioinformatic analysis constitute a powerful new methodology that can discriminate pathology from normal healthy tissue in a rapid, unbiased fashion, with high sensitivity and specificity. Notably, the ability to detect protein secondary structural changes associated with Alzheimer's plaques, neurons in Parkinson's disease, and in some spectra from meningioma, as well as in the animal models of Alzheimer's disease, transmissible spongiform encephalopathies, and multiple sclerosis, illustrates the power of this technology. The capacity to offer insight into the biochemical and structural changes underpinning aetio-pathogenesis of diseases in tissues provides both a platform to investigate early pathologies occurring in a variety of experimentally induced and naturally occurring central nervous system diseases, and the potential to evaluate new therapeutic approaches." @default.
• W1995373608 created "2016-06-24" @default.
• W1995373608 creator A5014787555 @default.
• W1995373608 creator A5034012619 @default.
• W1995373608 creator A5057712939 @default.
• W1995373608 creator A5059721051 @default.
• W1995373608 creator A5068590504 @default.
• W1995373608 date "2012-02-01" @default.
• W1995373608 modified "2023-10-17" @default.
• W1995373608 title "The application of Fourier transform infrared microspectroscopy for the study of diseased central nervous system tissue" @default.
• W1995373608 cites W1485459398 @default.
• W1995373608 cites W1966773116 @default.
• W1995373608 cites W1975082963 @default.
• W1995373608 cites W1975856048 @default.
• W1995373608 cites W1979594063 @default.
• W1995373608 cites W1980515691 @default.
• W1995373608 cites W1981014506 @default.
• W1995373608 cites W1981368729 @default.
• W1995373608 cites W1981753113 @default.
• W1995373608 cites W1982495620 @default.
• W1995373608 cites W1984858613 @default.
• W1995373608 cites W1984993288 @default.
• W1995373608 cites W1985310175 @default.
• W1995373608 cites W1987046316 @default.
• W1995373608 cites W1987389391 @default.
• W1995373608 cites W1987955706 @default.
• W1995373608 cites W1989146486 @default.
• W1995373608 cites W1989502043 @default.
• W1995373608 cites W1990201622 @default.
• W1995373608 cites W1992419399 @default.
• W1995373608 cites W1992791257 @default.
• W1995373608 cites W1992812982 @default.
• W1995373608 cites W1994689886 @default.
• W1995373608 cites W1999711723 @default.
• W1995373608 cites W1999841086 @default.
• W1995373608 cites W2000431734 @default.
• W1995373608 cites W2001499698 @default.
• W1995373608 cites W2001619934 @default.
• W1995373608 cites W2004128332 @default.
• W1995373608 cites W2004417000 @default.
• W1995373608 cites W2006929881 @default.
• W1995373608 cites W2007249865 @default.
• W1995373608 cites W2008315227 @default.
• W1995373608 cites W2012541956 @default.
• W1995373608 cites W2013679718 @default.
• W1995373608 cites W2013800800 @default.
• W1995373608 cites W2015660037 @default.
• W1995373608 cites W2016381774 @default.
• W1995373608 cites W2016948872 @default.
• W1995373608 cites W2018043821 @default.
• W1995373608 cites W2024560733 @default.
• W1995373608 cites W2024971501 @default.
• W1995373608 cites W2025514142 @default.
• W1995373608 cites W2027322045 @default.
• W1995373608 cites W2028064032 @default.
• W1995373608 cites W2029673488 @default.
• W1995373608 cites W2030657258 @default.
• W1995373608 cites W2031053150 @default.
• W1995373608 cites W2031084992 @default.
• W1995373608 cites W2031827286 @default.
• W1995373608 cites W2032575715 @default.
• W1995373608 cites W2034163178 @default.
• W1995373608 cites W2035252097 @default.
• W1995373608 cites W2035812748 @default.
• W1995373608 cites W2037358395 @default.
• W1995373608 cites W2038707973 @default.
• W1995373608 cites W2039439230 @default.
• W1995373608 cites W2039692707 @default.
• W1995373608 cites W2040286733 @default.
• W1995373608 cites W2040887679 @default.
• W1995373608 cites W2043349316 @default.
• W1995373608 cites W2043681221 @default.
• W1995373608 cites W2044892619 @default.
• W1995373608 cites W2048778471 @default.
• W1995373608 cites W2048992185 @default.
• W1995373608 cites W2049702244 @default.
• W1995373608 cites W2051791536 @default.
• W1995373608 cites W2052590218 @default.
• W1995373608 cites W2052644415 @default.
• W1995373608 cites W2052837082 @default.
• W1995373608 cites W2053667508 @default.
• W1995373608 cites W2054941965 @default.
• W1995373608 cites W2055664824 @default.
• W1995373608 cites W2056158724 @default.
• W1995373608 cites W2057308596 @default.
• W1995373608 cites W2057588337 @default.
• W1995373608 cites W2057649946 @default.
• W1995373608 cites W2058777180 @default.
• W1995373608 cites W2059111926 @default.
• W1995373608 cites W2062102053 @default.
• W1995373608 cites W2062848325 @default.
• W1995373608 cites W2062889098 @default.
• W1995373608 cites W2063496003 @default.
• W1995373608 cites W2064867676 @default.
• W1995373608 cites W2065338300 @default.
• W1995373608 cites W2066384243 @default.
• W1995373608 cites W2066665429 @default.
• W1995373608 cites W2066849157 @default.

• next