Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995376012> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W1995376012 endingPage "495" @default.
- W1995376012 startingPage "491" @default.
- W1995376012 abstract "The synthesis of 2-oxo- 5β-steroids (5β-cholestan-2-one and methyl 2-oxocholanate) and their derivatives have been described. Both oxo-steroids were prepared from 2β-acetoxy-3-oxo- 5β-ste-roids according to the following synthetic pathways: (a) condensation with ethylmercaptan to diethylmercaptol, desulfurization, hydrolysis and oxidation, (b) condensation with ethylmercaptan to diethylmercaptol, hydrolysis to hydroxy-ethylmercaptol, desulfurization and oxidation, and (c) isomerisation to 3α-acetoxy-2-oxo derivative and deacetylation with zinc powder to 2-oxo derivative. In these pathways, it was found that method (b) gave the best yield. On the other hand, desulfurization of the hydroxy-mercaptols with one-half the weight of Raney nickel used for that of method (b) gave 2β-hydroxy- 3β-ethylthio derivatives as intermediates. Reductive cleavage of these hydroxy-ethylthio derivatives with Raney nickel produced 2β-hydroxy- 5β-steroids in good yields. In the halogenation of these 2-oxo derivatives, the produc..." @default.
- W1995376012 created "2016-06-24" @default.
- W1995376012 creator A5018580308 @default.
- W1995376012 creator A5034175904 @default.
- W1995376012 creator A5075396701 @default.
- W1995376012 date "1970-02-01" @default.
- W1995376012 modified "2023-09-25" @default.
- W1995376012 title "A-Substituted 5β-Steroids. III. Synthesis of 2-Oxo- 5β-steroids and Their Derivatives" @default.
- W1995376012 cites W1997113805 @default.
- W1995376012 cites W2055324850 @default.
- W1995376012 cites W2072422689 @default.
- W1995376012 cites W2098255907 @default.
- W1995376012 cites W2113758738 @default.
- W1995376012 cites W2322690698 @default.
- W1995376012 cites W2329926016 @default.
- W1995376012 cites W2332502464 @default.
- W1995376012 cites W2332842652 @default.
- W1995376012 doi "https://doi.org/10.1246/bcsj.43.491" @default.
- W1995376012 hasPublicationYear "1970" @default.
- W1995376012 type Work @default.
- W1995376012 sameAs 1995376012 @default.
- W1995376012 citedByCount "5" @default.
- W1995376012 crossrefType "journal-article" @default.
- W1995376012 hasAuthorship W1995376012A5018580308 @default.
- W1995376012 hasAuthorship W1995376012A5034175904 @default.
- W1995376012 hasAuthorship W1995376012A5075396701 @default.
- W1995376012 hasBestOaLocation W19953760121 @default.
- W1995376012 hasConcept C155647269 @default.
- W1995376012 hasConcept C178790620 @default.
- W1995376012 hasConcept C185592680 @default.
- W1995376012 hasConcept C21951064 @default.
- W1995376012 hasConceptScore W1995376012C155647269 @default.
- W1995376012 hasConceptScore W1995376012C178790620 @default.
- W1995376012 hasConceptScore W1995376012C185592680 @default.
- W1995376012 hasConceptScore W1995376012C21951064 @default.
- W1995376012 hasIssue "2" @default.
- W1995376012 hasLocation W19953760121 @default.
- W1995376012 hasOpenAccess W1995376012 @default.
- W1995376012 hasPrimaryLocation W19953760121 @default.
- W1995376012 hasRelatedWork W2315647579 @default.
- W1995376012 hasRelatedWork W2341530064 @default.
- W1995376012 hasRelatedWork W2605844409 @default.
- W1995376012 hasRelatedWork W2605935158 @default.
- W1995376012 hasRelatedWork W2606081567 @default.
- W1995376012 hasRelatedWork W2606140458 @default.
- W1995376012 hasRelatedWork W2606340465 @default.
- W1995376012 hasRelatedWork W2606397491 @default.
- W1995376012 hasRelatedWork W2606566173 @default.
- W1995376012 hasRelatedWork W2606719653 @default.
- W1995376012 hasVolume "43" @default.
- W1995376012 isParatext "false" @default.
- W1995376012 isRetracted "false" @default.
- W1995376012 magId "1995376012" @default.
- W1995376012 workType "article" @default.