FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995376677> ?p ?o ?g. }

• W1995376677 endingPage "e109682" @default.
• W1995376677 startingPage "e109682" @default.
• W1995376677 abstract "Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by PTPN11, regulates signaling networks and cell fate in many tissues. Expression of oncogenic PTPN11 in the hematopoietic compartment causes myeloproliferative neoplasm (MPN) in humans and mice. However, the stage-specific effect(s) of mutant Ptpn11 on erythroid development have remained unknown. We found that expression of an activated, leukemogenic Ptpn11 allele, Ptpn11D61Y, specifically in the erythroid lineage causes dyserythropoiesis in mice. Ptpn11D61Y progenitors produce excess cKIT+CD71+Ter119− cells and aberrant numbers of cKITl°CD71+ erythroblasts. Mutant erythroblasts show elevated activation of ERK, AKT and STAT3 in response to EPO stimulation, and MEK inhibitor treatment blocks Ptpn11D61Y-evoked erythroid hyperproliferation in vitro. Thus, the expression of oncogenic Ptpn11 causes dyserythropoiesis in a cell-autonomous manner in vivo." @default.
• W1995376677 created "2016-06-24" @default.
• W1995376677 creator A5001007483 @default.
• W1995376677 creator A5019250915 @default.
• W1995376677 creator A5061899406 @default.
• W1995376677 creator A5063690344 @default.
• W1995376677 creator A5074819403 @default.
• W1995376677 date "2014-10-07" @default.
• W1995376677 modified "2023-10-14" @default.
• W1995376677 title "Leukemogenic Ptpn11 Allele Causes Defective Erythropoiesis in Mice" @default.
• W1995376677 cites W1555123423 @default.
• W1995376677 cites W1983806724 @default.
• W1995376677 cites W1984156926 @default.
• W1995376677 cites W2020562174 @default.
• W1995376677 cites W2061122212 @default.
• W1995376677 cites W2066372442 @default.
• W1995376677 cites W2072037914 @default.
• W1995376677 cites W2075607637 @default.
• W1995376677 cites W2075991830 @default.
• W1995376677 cites W2076904179 @default.
• W1995376677 cites W2081635903 @default.
• W1995376677 cites W2088044493 @default.
• W1995376677 cites W2113349387 @default.
• W1995376677 cites W2131444433 @default.
• W1995376677 doi "https://doi.org/10.1371/journal.pone.0109682" @default.
• W1995376677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4188809" @default.
• W1995376677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25289670" @default.
• W1995376677 hasPublicationYear "2014" @default.
• W1995376677 type Work @default.
• W1995376677 sameAs 1995376677 @default.
• W1995376677 citedByCount "8" @default.
• W1995376677 countsByYear W19953766772015 @default.
• W1995376677 countsByYear W19953766772016 @default.
• W1995376677 countsByYear W19953766772017 @default.
• W1995376677 countsByYear W19953766772018 @default.
• W1995376677 countsByYear W19953766772022 @default.
• W1995376677 crossrefType "journal-article" @default.
• W1995376677 hasAuthorship W1995376677A5001007483 @default.
• W1995376677 hasAuthorship W1995376677A5019250915 @default.
• W1995376677 hasAuthorship W1995376677A5061899406 @default.
• W1995376677 hasAuthorship W1995376677A5063690344 @default.
• W1995376677 hasAuthorship W1995376677A5074819403 @default.
• W1995376677 hasBestOaLocation W19953766771 @default.
• W1995376677 hasConcept C104317684 @default.
• W1995376677 hasConcept C109159458 @default.
• W1995376677 hasConcept C126322002 @default.
• W1995376677 hasConcept C153911025 @default.
• W1995376677 hasConcept C201750760 @default.
• W1995376677 hasConcept C2778248108 @default.
• W1995376677 hasConcept C2779703530 @default.
• W1995376677 hasConcept C2780844101 @default.
• W1995376677 hasConcept C2781187634 @default.
• W1995376677 hasConcept C28328180 @default.
• W1995376677 hasConcept C31734879 @default.
• W1995376677 hasConcept C501734568 @default.
• W1995376677 hasConcept C502942594 @default.
• W1995376677 hasConcept C54355233 @default.
• W1995376677 hasConcept C57074206 @default.
• W1995376677 hasConcept C62478195 @default.
• W1995376677 hasConcept C71924100 @default.
• W1995376677 hasConcept C86803240 @default.
• W1995376677 hasConcept C95444343 @default.
• W1995376677 hasConceptScore W1995376677C104317684 @default.
• W1995376677 hasConceptScore W1995376677C109159458 @default.
• W1995376677 hasConceptScore W1995376677C126322002 @default.
• W1995376677 hasConceptScore W1995376677C153911025 @default.
• W1995376677 hasConceptScore W1995376677C201750760 @default.
• W1995376677 hasConceptScore W1995376677C2778248108 @default.
• W1995376677 hasConceptScore W1995376677C2779703530 @default.
• W1995376677 hasConceptScore W1995376677C2780844101 @default.
• W1995376677 hasConceptScore W1995376677C2781187634 @default.
• W1995376677 hasConceptScore W1995376677C28328180 @default.
• W1995376677 hasConceptScore W1995376677C31734879 @default.
• W1995376677 hasConceptScore W1995376677C501734568 @default.
• W1995376677 hasConceptScore W1995376677C502942594 @default.
• W1995376677 hasConceptScore W1995376677C54355233 @default.
• W1995376677 hasConceptScore W1995376677C57074206 @default.
• W1995376677 hasConceptScore W1995376677C62478195 @default.
• W1995376677 hasConceptScore W1995376677C71924100 @default.
• W1995376677 hasConceptScore W1995376677C86803240 @default.
• W1995376677 hasConceptScore W1995376677C95444343 @default.
• W1995376677 hasIssue "10" @default.
• W1995376677 hasLocation W19953766771 @default.
• W1995376677 hasLocation W19953766772 @default.
• W1995376677 hasLocation W19953766773 @default.
• W1995376677 hasLocation W19953766774 @default.
• W1995376677 hasLocation W19953766775 @default.
• W1995376677 hasOpenAccess W1995376677 @default.
• W1995376677 hasPrimaryLocation W19953766771 @default.
• W1995376677 hasRelatedWork W2004726042 @default.
• W1995376677 hasRelatedWork W2008532188 @default.
• W1995376677 hasRelatedWork W2046988630 @default.
• W1995376677 hasRelatedWork W2381340599 @default.
• W1995376677 hasRelatedWork W2462039273 @default.
• W1995376677 hasRelatedWork W2472644284 @default.
• W1995376677 hasRelatedWork W2516866347 @default.
• W1995376677 hasRelatedWork W2885811882 @default.
• W1995376677 hasRelatedWork W3132926045 @default.

• next