FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995377908> ?p ?o ?g. }

• W1995377908 endingPage "658" @default.
• W1995377908 startingPage "650" @default.
• W1995377908 abstract "Rationale: Epidemiologic data indicate an increased incidence of asthma in the obese.Objectives: To determine whether obese mice exhibit augmented pulmonary responses after allergen sensitization and challenge.Methods: Lean, wild-type (C57BL/6), obese ob/ob, and obese db/db mice were sensitized to ovalbumin (OVA), and then challenged with aerosolized OVA or phosphate-buffered saline (PBS). Changes in total pulmonary resistance (Rl) induced by intravenous methacholine were measured by forced oscillation. Blood was collected, bronchoalveolar lavage (BAL) was performed, and lungs were harvested for measurement of cytokine expression by real-time reverse transcription–polymerase chain reaction.Measurements and Main Results: OVA challenge increased baseline Rl in ob/ob, but not wild-type, mice, and airway responsiveness was greater in ob/ob than wild-type mice, regardless of the challenge. Compared with PBS, OVA challenge caused an increase in the number of BAL fluid (BALF) cells, an increase in lung Th2 cytokine expression, and an increase in serum IgE. Significantly fewer BALF cells were recovered from OVA-challenged ob/ob versus wild-type mice, whereas serum IgE levels were elevated significantly more in ob/ob versus wild-type mice. BALF and lung Th2 cytokine expression was not different in ob/ob versus wild-type mice. Airway responsiveness was greater in db/db versus wild-type mice, regardless of the challenge, and OVA caused airway hyperresponsiveness in db/db but not wild-type mice, despite reduced BALF cells in OVA-challenged db/db versus wild-type mice.Conclusions: These results demonstrate that obesity enhances OVA-induced changes in pulmonary resistance and serum IgE and that these changes are not the result of increased Th2 type airway inflammation." @default.
• W1995377908 created "2016-06-24" @default.
• W1995377908 creator A5010404791 @default.
• W1995377908 creator A5016609809 @default.
• W1995377908 creator A5021100959 @default.
• W1995377908 creator A5043083920 @default.
• W1995377908 creator A5049845466 @default.
• W1995377908 creator A5067354166 @default.
• W1995377908 creator A5068560690 @default.
• W1995377908 date "2007-10-01" @default.
• W1995377908 modified "2023-10-05" @default.
• W1995377908 title "Allergic Airway Responses in Obese Mice" @default.
• W1995377908 cites W1566553022 @default.
• W1995377908 cites W1604037801 @default.
• W1995377908 cites W1967975205 @default.
• W1995377908 cites W1968335934 @default.
• W1995377908 cites W1968450602 @default.
• W1995377908 cites W1970584672 @default.
• W1995377908 cites W1973019664 @default.
• W1995377908 cites W1973228855 @default.
• W1995377908 cites W1979346304 @default.
• W1995377908 cites W1979764360 @default.
• W1995377908 cites W1983435593 @default.
• W1995377908 cites W1992119116 @default.
• W1995377908 cites W1993901681 @default.
• W1995377908 cites W1998419834 @default.
• W1995377908 cites W1998962160 @default.
• W1995377908 cites W2000647726 @default.
• W1995377908 cites W2010135843 @default.
• W1995377908 cites W2015493089 @default.
• W1995377908 cites W2016979581 @default.
• W1995377908 cites W2020517742 @default.
• W1995377908 cites W2028152306 @default.
• W1995377908 cites W2031972979 @default.
• W1995377908 cites W2034804696 @default.
• W1995377908 cites W2048130372 @default.
• W1995377908 cites W2048977391 @default.
• W1995377908 cites W2059652342 @default.
• W1995377908 cites W2061376514 @default.
• W1995377908 cites W2061453728 @default.
• W1995377908 cites W2071073097 @default.
• W1995377908 cites W2072705074 @default.
• W1995377908 cites W2073412359 @default.
• W1995377908 cites W2078201105 @default.
• W1995377908 cites W2085077833 @default.
• W1995377908 cites W2089888103 @default.
• W1995377908 cites W2091329141 @default.
• W1995377908 cites W2101035994 @default.
• W1995377908 cites W2103197729 @default.
• W1995377908 cites W2109027736 @default.
• W1995377908 cites W2114081281 @default.
• W1995377908 cites W2116338090 @default.
• W1995377908 cites W2117179008 @default.
• W1995377908 cites W2120897861 @default.
• W1995377908 cites W2121487574 @default.
• W1995377908 cites W2124425047 @default.
• W1995377908 cites W2124566107 @default.
• W1995377908 cites W2125805192 @default.
• W1995377908 cites W2128089720 @default.
• W1995377908 cites W2129015734 @default.
• W1995377908 cites W2129316761 @default.
• W1995377908 cites W2130766522 @default.
• W1995377908 cites W2140942460 @default.
• W1995377908 cites W2142302739 @default.
• W1995377908 cites W2143199340 @default.
• W1995377908 cites W2160309307 @default.
• W1995377908 cites W2160548369 @default.
• W1995377908 cites W2161950337 @default.
• W1995377908 cites W2164686510 @default.
• W1995377908 cites W2165302519 @default.
• W1995377908 cites W2167028507 @default.
• W1995377908 cites W2168248213 @default.
• W1995377908 cites W2170428651 @default.
• W1995377908 cites W4231671798 @default.
• W1995377908 cites W4235838570 @default.
• W1995377908 cites W4240093176 @default.
• W1995377908 doi "https://doi.org/10.1164/rccm.200702-323oc" @default.
• W1995377908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1994235" @default.
• W1995377908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17641156" @default.
• W1995377908 hasPublicationYear "2007" @default.
• W1995377908 type Work @default.
• W1995377908 sameAs 1995377908 @default.
• W1995377908 citedByCount "130" @default.
• W1995377908 countsByYear W19953779082012 @default.
• W1995377908 countsByYear W19953779082013 @default.
• W1995377908 countsByYear W19953779082014 @default.
• W1995377908 countsByYear W19953779082015 @default.
• W1995377908 countsByYear W19953779082016 @default.
• W1995377908 countsByYear W19953779082017 @default.
• W1995377908 countsByYear W19953779082018 @default.
• W1995377908 countsByYear W19953779082019 @default.
• W1995377908 countsByYear W19953779082020 @default.
• W1995377908 countsByYear W19953779082021 @default.
• W1995377908 countsByYear W19953779082022 @default.
• W1995377908 countsByYear W19953779082023 @default.
• W1995377908 crossrefType "journal-article" @default.
• W1995377908 hasAuthorship W1995377908A5010404791 @default.
• W1995377908 hasAuthorship W1995377908A5016609809 @default.

• next