Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995386236> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1995386236 endingPage "7709" @default.
- W1995386236 startingPage "7705" @default.
- W1995386236 abstract "The cyclic enzymatic function of a cytochrome P450, as it catalyzes the oxygen-dependent metabolism of many organic chemicals, requires the delivery of two electrons to the hemeprotein. In general these electrons are transferred from NADPH to the P450 via an FMN- and FAD-containing flavoprotein (NADPH-P450 reductase). The present paper shows that NADPH can be replaced by an electrochemically generated reductant [cobalt(II) sepulchrate trichloride] for the electrocatalytically driven omega-hydroxylation of lauric acid. Results are presented illustrating the use of purified recombinant proteins containing P450 4A1, such as the fusion protein (rFP450 [mRat4A1/mRatOR]L1) or a system reconstituted with purified P450 4A1 plus purified NADPH-P450 reductase. Rates of formation of 12-hydroxydodecanoic acid by the electrochemical method are comparable to those obtained using NADPH as electron donor. These results suggest the practicality of developing electrocatalytically dependent bioreactors containing different P450s as catalysts for the large-scale synthesis of stereo- and regio-selective hydroxylation products of many chemicals." @default.
- W1995386236 created "2016-06-24" @default.
- W1995386236 creator A5000962788 @default.
- W1995386236 creator A5017397486 @default.
- W1995386236 creator A5078755670 @default.
- W1995386236 creator A5088252762 @default.
- W1995386236 date "1995-08-15" @default.
- W1995386236 modified "2023-10-17" @default.
- W1995386236 title "Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1." @default.
- W1995386236 cites W1501985924 @default.
- W1995386236 cites W1579297624 @default.
- W1995386236 cites W1976958634 @default.
- W1995386236 cites W1983550144 @default.
- W1995386236 cites W1989730305 @default.
- W1995386236 cites W2013019511 @default.
- W1995386236 cites W2019518728 @default.
- W1995386236 cites W2028487503 @default.
- W1995386236 cites W2061333433 @default.
- W1995386236 cites W2150946709 @default.
- W1995386236 cites W2169838870 @default.
- W1995386236 doi "https://doi.org/10.1073/pnas.92.17.7705" @default.
- W1995386236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41214" @default.
- W1995386236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7644480" @default.
- W1995386236 hasPublicationYear "1995" @default.
- W1995386236 type Work @default.
- W1995386236 sameAs 1995386236 @default.
- W1995386236 citedByCount "88" @default.
- W1995386236 countsByYear W19953862362012 @default.
- W1995386236 countsByYear W19953862362013 @default.
- W1995386236 countsByYear W19953862362014 @default.
- W1995386236 countsByYear W19953862362015 @default.
- W1995386236 countsByYear W19953862362016 @default.
- W1995386236 countsByYear W19953862362017 @default.
- W1995386236 countsByYear W19953862362018 @default.
- W1995386236 countsByYear W19953862362020 @default.
- W1995386236 countsByYear W19953862362022 @default.
- W1995386236 countsByYear W19953862362023 @default.
- W1995386236 crossrefType "journal-article" @default.
- W1995386236 hasAuthorship W1995386236A5000962788 @default.
- W1995386236 hasAuthorship W1995386236A5017397486 @default.
- W1995386236 hasAuthorship W1995386236A5078755670 @default.
- W1995386236 hasAuthorship W1995386236A5088252762 @default.
- W1995386236 hasBestOaLocation W19953862362 @default.
- W1995386236 hasConcept C134651460 @default.
- W1995386236 hasConcept C181199279 @default.
- W1995386236 hasConcept C185592680 @default.
- W1995386236 hasConcept C24840226 @default.
- W1995386236 hasConcept C2781003072 @default.
- W1995386236 hasConcept C2781109383 @default.
- W1995386236 hasConcept C526171541 @default.
- W1995386236 hasConcept C543025807 @default.
- W1995386236 hasConcept C55493867 @default.
- W1995386236 hasConcept C71995715 @default.
- W1995386236 hasConceptScore W1995386236C134651460 @default.
- W1995386236 hasConceptScore W1995386236C181199279 @default.
- W1995386236 hasConceptScore W1995386236C185592680 @default.
- W1995386236 hasConceptScore W1995386236C24840226 @default.
- W1995386236 hasConceptScore W1995386236C2781003072 @default.
- W1995386236 hasConceptScore W1995386236C2781109383 @default.
- W1995386236 hasConceptScore W1995386236C526171541 @default.
- W1995386236 hasConceptScore W1995386236C543025807 @default.
- W1995386236 hasConceptScore W1995386236C55493867 @default.
- W1995386236 hasConceptScore W1995386236C71995715 @default.
- W1995386236 hasIssue "17" @default.
- W1995386236 hasLocation W19953862361 @default.
- W1995386236 hasLocation W19953862362 @default.
- W1995386236 hasLocation W19953862363 @default.
- W1995386236 hasLocation W19953862364 @default.
- W1995386236 hasOpenAccess W1995386236 @default.
- W1995386236 hasPrimaryLocation W19953862361 @default.
- W1995386236 hasRelatedWork W1966054354 @default.
- W1995386236 hasRelatedWork W1995386236 @default.
- W1995386236 hasRelatedWork W2029733973 @default.
- W1995386236 hasRelatedWork W2061416714 @default.
- W1995386236 hasRelatedWork W2079680315 @default.
- W1995386236 hasRelatedWork W2094948961 @default.
- W1995386236 hasRelatedWork W2228086802 @default.
- W1995386236 hasRelatedWork W2395597369 @default.
- W1995386236 hasRelatedWork W2397136039 @default.
- W1995386236 hasRelatedWork W2470391922 @default.
- W1995386236 hasVolume "92" @default.
- W1995386236 isParatext "false" @default.
- W1995386236 isRetracted "false" @default.
- W1995386236 magId "1995386236" @default.
- W1995386236 workType "article" @default.