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- W1995411470 abstract "1. 1-(2-Pyrimidinyl)-piperazine (PmP) is a common metabolite of the structurally related drugs buspirone, MJ-13805 and piribedil.2. After i.v. injection (25 μmol/kg) to rats, all three parent drugs are rapidly cleared with a t1/2 (β) of about 30 min. The metabolite t1/2 is about four times that of its parent drugs.3. About 25, 23 and 2% of buspirone, MJ-13805 and piribedil, respectively, reaches the systemic circulation as PmP. The metabolite concentrates in the brain where its A.U.C. is about twice those of buspirone and MJ-13805.4. Results indicate that PmP formation is a pharmacologically significant process for both buspirone and MJ-13805 but it is probably less important for piribedil." @default.
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- W1995411470 date "1985-01-01" @default.
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- W1995411470 title "Disposition of the psychotropic drugs buspirone, MJ-13805 and piribedil, and of their common active metabolite 1-(2-pyrimidinyl)-piperazine in the rat" @default.
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- W1995411470 doi "https://doi.org/10.3109/00498258509045035" @default.
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