Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995413426> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1995413426 endingPage "480" @default.
- W1995413426 startingPage "467" @default.
- W1995413426 abstract "Objective: To review the main pharmacological properties and clinical applications of the drugs used in the medical therapy of Cushings syndrome. Data Sources: Search for articles were performed in the following dababases: MEDLINE, EMBASE, Cochrane Database of systematic Reviews and The Cochrane Central Register of Controlled Trials (CENTRAL). Search terms included Cushings syndrome and drug therapy. Data Synthesis: Available data suggest that neuromodulatory compounds affect corticotropin (ACTH) or ACTH-releasing hormone (CRH) synthesis and release. They include serotonin antagonists, dopaminergic agonists, valproic acid, reserpine, somatostatin analogs and thiazolidinediones. These agents have been effective in a limited number of patients with ACTH-dependent Cushings syndrome. Inhibitors of steroidogenesis reduce cortisol production by blocking one (metyrapone, trilostane) or several (aminoglutethimide, ketoconazole, fluconazole, etomidate) enzymes involved in steroid biosynthesis. Mitotane is a steroidogenesis inhibitor with adrenolitic properties. Mifepristone blocks glucocorticoid receptor activation without modifying cortisol synthesis. Conclusion: Agents that inhibit steroidogenesis are useful in all forms of Cushings syndrome and are effective in about 70% of patients. Main indications for drug therapy include preparation for surgery, persistence or recurrence after surgery, while awaiting for the effect of radiation therapy, occult ectopic ACTH syndrome, severe hypercortisolism and malignancy related hypercortisolism. Keywords: Cushing's syndrome, drug therapy, cortisol, corticotropin" @default.
- W1995413426 created "2016-06-24" @default.
- W1995413426 creator A5070475556 @default.
- W1995413426 creator A5079637727 @default.
- W1995413426 date "2007-05-01" @default.
- W1995413426 modified "2023-10-12" @default.
- W1995413426 title "Pharmacological Therapy of Cushings Syndrome: Drugs and Indications" @default.
- W1995413426 doi "https://doi.org/10.2174/138955707780619653" @default.
- W1995413426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17504182" @default.
- W1995413426 hasPublicationYear "2007" @default.
- W1995413426 type Work @default.
- W1995413426 sameAs 1995413426 @default.
- W1995413426 citedByCount "32" @default.
- W1995413426 countsByYear W19954134262012 @default.
- W1995413426 countsByYear W19954134262013 @default.
- W1995413426 countsByYear W19954134262014 @default.
- W1995413426 countsByYear W19954134262015 @default.
- W1995413426 countsByYear W19954134262016 @default.
- W1995413426 countsByYear W19954134262017 @default.
- W1995413426 countsByYear W19954134262018 @default.
- W1995413426 countsByYear W19954134262023 @default.
- W1995413426 crossrefType "journal-article" @default.
- W1995413426 hasAuthorship W1995413426A5070475556 @default.
- W1995413426 hasAuthorship W1995413426A5079637727 @default.
- W1995413426 hasConcept C121608353 @default.
- W1995413426 hasConcept C126322002 @default.
- W1995413426 hasConcept C134018914 @default.
- W1995413426 hasConcept C143998085 @default.
- W1995413426 hasConcept C16005928 @default.
- W1995413426 hasConcept C2775976807 @default.
- W1995413426 hasConcept C2776166826 @default.
- W1995413426 hasConcept C2776694085 @default.
- W1995413426 hasConcept C2776719974 @default.
- W1995413426 hasConcept C2776735609 @default.
- W1995413426 hasConcept C2778826759 @default.
- W1995413426 hasConcept C2779234561 @default.
- W1995413426 hasConcept C2779548794 @default.
- W1995413426 hasConcept C2781064554 @default.
- W1995413426 hasConcept C530470458 @default.
- W1995413426 hasConcept C54355233 @default.
- W1995413426 hasConcept C71924100 @default.
- W1995413426 hasConcept C86803240 @default.
- W1995413426 hasConcept C98274493 @default.
- W1995413426 hasConceptScore W1995413426C121608353 @default.
- W1995413426 hasConceptScore W1995413426C126322002 @default.
- W1995413426 hasConceptScore W1995413426C134018914 @default.
- W1995413426 hasConceptScore W1995413426C143998085 @default.
- W1995413426 hasConceptScore W1995413426C16005928 @default.
- W1995413426 hasConceptScore W1995413426C2775976807 @default.
- W1995413426 hasConceptScore W1995413426C2776166826 @default.
- W1995413426 hasConceptScore W1995413426C2776694085 @default.
- W1995413426 hasConceptScore W1995413426C2776719974 @default.
- W1995413426 hasConceptScore W1995413426C2776735609 @default.
- W1995413426 hasConceptScore W1995413426C2778826759 @default.
- W1995413426 hasConceptScore W1995413426C2779234561 @default.
- W1995413426 hasConceptScore W1995413426C2779548794 @default.
- W1995413426 hasConceptScore W1995413426C2781064554 @default.
- W1995413426 hasConceptScore W1995413426C530470458 @default.
- W1995413426 hasConceptScore W1995413426C54355233 @default.
- W1995413426 hasConceptScore W1995413426C71924100 @default.
- W1995413426 hasConceptScore W1995413426C86803240 @default.
- W1995413426 hasConceptScore W1995413426C98274493 @default.
- W1995413426 hasIssue "5" @default.
- W1995413426 hasLocation W19954134261 @default.
- W1995413426 hasLocation W19954134262 @default.
- W1995413426 hasOpenAccess W1995413426 @default.
- W1995413426 hasPrimaryLocation W19954134261 @default.
- W1995413426 hasRelatedWork W1536517901 @default.
- W1995413426 hasRelatedWork W1998673854 @default.
- W1995413426 hasRelatedWork W2013642547 @default.
- W1995413426 hasRelatedWork W2057637053 @default.
- W1995413426 hasRelatedWork W2093147952 @default.
- W1995413426 hasRelatedWork W2101248051 @default.
- W1995413426 hasRelatedWork W2333885721 @default.
- W1995413426 hasRelatedWork W2410352890 @default.
- W1995413426 hasRelatedWork W2419267536 @default.
- W1995413426 hasRelatedWork W4240371759 @default.
- W1995413426 hasVolume "7" @default.
- W1995413426 isParatext "false" @default.
- W1995413426 isRetracted "false" @default.
- W1995413426 magId "1995413426" @default.
- W1995413426 workType "article" @default.