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- W1995413703 abstract "Aim: The pathogenic role of soluble endoglin (s-Eng), as an antiangiogenic protein, has largely been demonstrated in various vascular disorders. Our aim was to assess, in a cross-sectional study, plasma levels of s-Eng in systemic lupus erythematosus (SLE) patients and its relation with the disease characteristics. Patients and methods: Plasma from 86 patients with SLE and 36 normal healthy subjects was assayed for s-Eng levels by enzyme-linked immunosorbent assay. Demographic, clinical, autoantibodies and serological data were prospectively assessed. Disease activity was assessed by total SLE disease activity index score. Results: In our SLE patients, the levels of s-Eng were comparable between SLE patients and the control group. However, these levels were significantly associated with antiphospholipid syndrome (APS). In addition, s-Eng levels were significantly associated with antiphospholipid antibodies in our studied population. On the other hand, we did not find significant differences in mean plasma s-Eng levels in relation to disease activity, other organ system involvement or the presence of anti-dsDNA. Conclusion: Our preliminary data indicated the importance of s-Eng in a special subgroup of SLE patients associated with secondary APS. An additional prospective, large-scale, longitudinal study should be carried out to support these findings." @default.
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- W1995413703 date "2012-08-31" @default.
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- W1995413703 title "Clinical significance of soluble-endoglin levels in systemic lupus erythematosus: possible association with anti-phospholipid syndrome" @default.
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- W1995413703 doi "https://doi.org/10.1177/0961203312460115" @default.
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