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- W1995414918 abstract "Lymphocytes of eleven normal subjects were studied with autoradiographic techniques for the presence of cells which bind human 125I-thyroglobulin (Tg). In nine out of eleven subjects an average of 0·02% were able to bind 125I-Tg. In three other subjects no lymphocytes able to bind human serum albumin were detected. A double-layer anti-human immunoglobulin (Ig)-coated bead column was used to prepare lymphocyte suspensions depleted of cells with a large amount of surface-bound Ig (B lymphocytes). The lymphocyte suspension after column passage contained an average of 99% lymphocytes without easily detectable surface-bound Ig (T lymphocytes). The lymphocytes which bind 125I-Tg were identified primarily as B lymphocytes in four patients by their marked or complete depletion after passage through this column. These results are discussed in terms of possible mechanisms involved in autoimmunity." @default.
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- W1995414918 date "1973-02-01" @default.
- W1995414918 modified "2023-09-26" @default.
- W1995414918 title "LYMPHOCYTES BINDING HUMAN THYROGLOBULIN IN HEALTHY PEOPLE AND ITS RELEVANCE TO TOLERANCE FOR AUTOANTIGENS" @default.
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- W1995414918 doi "https://doi.org/10.1016/s0140-6736(73)90066-4" @default.
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