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• W1995415930 abstract "Objective: It is of fundamental importance for ART programs to determine the most viable embryo for transfer. At the same time the program must reduce the risk of multiple births and still maximize the chances of pregnancy for their patients. In this study we evaluate the accuracy of experienced investigators in identifying embryos on Day 3 that will result in the best subsequent blastocysts for transfer on Day 5. We then compared these results to those of a computer algorithm based on sequential embryo assessment of multiple early morphological markers. Material and Methods: One hundred eleven patients underwent a Day 5 (blastocyst stage) embryo transfer during 2001 and the first 6 months of 2002 at our ART program. From the 2001 database, 3 investigators were asked to select which embryos they would recommend for transfer based only on the embryo development stages up to Day 3, the patient’s age and her IVF/ICSI status. After analysis of their 2001 results and review of embryo scoring techniques the same investigators performed selections from the 2002 database. From the 2002 database a computer model selected 3 Day 3 embryos for Day 5 transfers based on a sequential scoring system that takes into account multiple morphological stages, beginning with pronuclear alignment, length of first cell cycle and cleavage stages (>4 and >8 cell stage) on Day 2 and 3 of development. Results: In 2001 the best embryo available on Day 5 was successfully selected on Day 3 in just over 50% of the cases (Table 1). After analysis of the 2001 results by the three investigators there was a significant improvement in their ability to select a blastocyst with the 2002 data when one was available (p = 0.02). However, the computer model either equaled or outperformed the 3 investigators in selection performance. There was no statistically significant difference between any of the selections made by the 3 investigators. Tabled 1 Conclusions: Even experienced ART investigators have only a slightly better than 50% chance of selecting the best embryo based on Day 3 information. More importantly, our computer model using early embryo assessment criteria may provide a more reliable, objective way for selecting the optimal embryo for transfer on Day 3, and in addition has the potential to be a useful training and standardization tool for ART programs." @default.
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• W1995415930 date "2003-09-01" @default.
• W1995415930 modified "2023-10-18" @default.
• W1995415930 title "Is day 3 embryo quality indicative of day 5 blastocyst development? comparison of clinician vs. computer selection" @default.
• W1995415930 doi "https://doi.org/10.1016/s0015-0282(03)02051-x" @default.
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