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• W1995429319 endingPage "368" @default.
• W1995429319 startingPage "352" @default.
• W1995429319 abstract "Objectives: The polyphenol resveratrol has shown regulatory effects on hippocampal neurogenesis, which according to the neurovascular niche hypothesis, is likely to involve stimulation of angiogenesis. In rodents, global cerebral ischemia leads to selective CA1 neuronal damage, spatial memory impairments, lasting changes in corticosterone (CORT) secretion, and increased neurogenesis. This study examined dose-related effects of 21-day RSV treatment on markers associated with neurogenesis (DCX, PSA-NCAM) and angiogenesis (CD31) in the hippocampus at short (7-day) and long-term (85-day) intervals following global ischemia. In parallel, post-ischemic and stress-induced CORT levels and spatial memory in the Morris water maze were determined.Methods: Five groups of male Wistar rats were included: sham/saline, ischemia/saline, ischemia/1 mg/kg RSV, ischemia/10 mg/kg RSV, and sham/10 mg/kg RSV. Changes in expression of plasticity markers were paralleled by assessment of basal- and stress-induced CORT secretions, and spatial memory performance.Results: Our findings revealed a significant attenuation of ischemia-induced DCX/PSA-NCAM expression in RSV-treated rats, whereas RSV treatment increased angiogenesis in the injured CA1 region. RSV attenuated CORT levels 3 days post-ischemia and a trend toward attenuating CORT secretion in response to 15 minutes restraint stress. Increased swimming latencies in the target quadrant during the MWM probe trial in RSV-treated ischemic rats support beneficial effects of RSV on spatial memory retention.Discussion: Our findings uncover time- and dose-related effects of RSV and global ischemia on the regulation of hippocampal plasticity. Changes in neuro- and angiogenesis are consistent with RSV neuroprotective effects, but appear independent of RSV regulatory effects on corticosterone secretion." @default.
• W1995429319 created "2016-06-24" @default.
• W1995429319 creator A5011137556 @default.
• W1995429319 creator A5027246988 @default.
• W1995429319 creator A5040379352 @default.
• W1995429319 creator A5047539467 @default.
• W1995429319 date "2015-04-11" @default.
• W1995429319 modified "2023-09-25" @default.
• W1995429319 title "Dose-related effects of chronic resveratrol administration on neurogenesis, angiogenesis, and corticosterone secretion are associated with improved spatial memory retention following global cerebral ischemia" @default.
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• W1995429319 doi "https://doi.org/10.1179/1476830515y.0000000020" @default.
• W1995429319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25866012" @default.
• W1995429319 hasPublicationYear "2015" @default.
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