FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995438259> ?p ?o ?g. }

• W1995438259 abstract "The expression of bcl-2-related proteins has been shown to be a key element in tumoral malignancy. The degradation of the extracellular matrix (ECM) by specialized matrix metalloproteinases (MMPs) is another major step in tumor invasion and metastasis. We have examined, in a rat glioma cell line A15A5, the effect of the stable transfection of human bcl-2, bax and bcl-xl on MMPs expression. Using a zymographic assay, we found that all transfected cell lines expressed a gelatinase activity which is predominantly associated with MMP-9. In bcl-2 and bcl-xl transfected cells, the transcription of MMP-9 was decreased compared to that of control or bax transfected cells. In addition, in bax transfected A15A5, we observed a down regulation of TIMP-1, the inhibitor of MMP-9. These results suggest that the ratio between MMP-9 and its inhibitor TIMP-1 is tightly controlled in cells overexpressing bcl-2 related proteins (i.e., high ratio in bax transfected A15A5 and low ratio in bcl-2 transfected A15A5). However, MMPs secreted by bcl-2 transfected cells were still capable of hydrolyzing FasL present on human lymphocytes. Our results suggest that the expression of bcl-2 related proteins could participate in the regulation of MMP-9/TIMP-1 in gliomas." @default.
• W1995438259 created "2016-06-24" @default.
• W1995438259 creator A5018416621 @default.
• W1995438259 creator A5019128382 @default.
• W1995438259 creator A5019399557 @default.
• W1995438259 creator A5027603422 @default.
• W1995438259 creator A5028466138 @default.
• W1995438259 creator A5082204622 @default.
• W1995438259 creator A5085760118 @default.
• W1995438259 date "2000-07-01" @default.
• W1995438259 modified "2023-09-27" @default.
• W1995438259 title "Influence of bcl-2-Related Proteins on Matrix Metalloproteinase Expression in a Rat Glioma Cell Line" @default.
• W1995438259 cites W1602004990 @default.
• W1995438259 cites W1967193703 @default.
• W1995438259 cites W1983631836 @default.
• W1995438259 cites W1987197699 @default.
• W1995438259 cites W1988604363 @default.
• W1995438259 cites W1996980134 @default.
• W1995438259 cites W2006010682 @default.
• W1995438259 cites W2015660037 @default.
• W1995438259 cites W2020444230 @default.
• W1995438259 cites W2036797845 @default.
• W1995438259 cites W2069014461 @default.
• W1995438259 cites W2079241115 @default.
• W1995438259 cites W2091100304 @default.
• W1995438259 cites W2104577276 @default.
• W1995438259 cites W2108510669 @default.
• W1995438259 cites W2132411546 @default.
• W1995438259 cites W2164802863 @default.
• W1995438259 cites W2170507464 @default.
• W1995438259 cites W67975532 @default.
• W1995438259 doi "https://doi.org/10.1006/bbrc.2000.2952" @default.
• W1995438259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10873619" @default.
• W1995438259 hasPublicationYear "2000" @default.
• W1995438259 type Work @default.
• W1995438259 sameAs 1995438259 @default.
• W1995438259 citedByCount "14" @default.
• W1995438259 countsByYear W19954382592012 @default.
• W1995438259 countsByYear W19954382592013 @default.
• W1995438259 crossrefType "journal-article" @default.
• W1995438259 hasAuthorship W1995438259A5018416621 @default.
• W1995438259 hasAuthorship W1995438259A5019128382 @default.
• W1995438259 hasAuthorship W1995438259A5019399557 @default.
• W1995438259 hasAuthorship W1995438259A5027603422 @default.
• W1995438259 hasAuthorship W1995438259A5028466138 @default.
• W1995438259 hasAuthorship W1995438259A5082204622 @default.
• W1995438259 hasAuthorship W1995438259A5085760118 @default.
• W1995438259 hasConcept C109523444 @default.
• W1995438259 hasConcept C153911025 @default.
• W1995438259 hasConcept C185592680 @default.
• W1995438259 hasConcept C189165786 @default.
• W1995438259 hasConcept C2775965246 @default.
• W1995438259 hasConcept C2776223131 @default.
• W1995438259 hasConcept C2776232661 @default.
• W1995438259 hasConcept C2778227246 @default.
• W1995438259 hasConcept C502942594 @default.
• W1995438259 hasConcept C54009773 @default.
• W1995438259 hasConcept C54355233 @default.
• W1995438259 hasConcept C55493867 @default.
• W1995438259 hasConcept C81885089 @default.
• W1995438259 hasConcept C86803240 @default.
• W1995438259 hasConcept C95444343 @default.
• W1995438259 hasConceptScore W1995438259C109523444 @default.
• W1995438259 hasConceptScore W1995438259C153911025 @default.
• W1995438259 hasConceptScore W1995438259C185592680 @default.
• W1995438259 hasConceptScore W1995438259C189165786 @default.
• W1995438259 hasConceptScore W1995438259C2775965246 @default.
• W1995438259 hasConceptScore W1995438259C2776223131 @default.
• W1995438259 hasConceptScore W1995438259C2776232661 @default.
• W1995438259 hasConceptScore W1995438259C2778227246 @default.
• W1995438259 hasConceptScore W1995438259C502942594 @default.
• W1995438259 hasConceptScore W1995438259C54009773 @default.
• W1995438259 hasConceptScore W1995438259C54355233 @default.
• W1995438259 hasConceptScore W1995438259C55493867 @default.
• W1995438259 hasConceptScore W1995438259C81885089 @default.
• W1995438259 hasConceptScore W1995438259C86803240 @default.
• W1995438259 hasConceptScore W1995438259C95444343 @default.
• W1995438259 hasLocation W19954382591 @default.
• W1995438259 hasLocation W19954382592 @default.
• W1995438259 hasOpenAccess W1995438259 @default.
• W1995438259 hasPrimaryLocation W19954382591 @default.
• W1995438259 hasRelatedWork W1223174617 @default.
• W1995438259 hasRelatedWork W1526902551 @default.
• W1995438259 hasRelatedWork W1966959678 @default.
• W1995438259 hasRelatedWork W2035468900 @default.
• W1995438259 hasRelatedWork W2063771052 @default.
• W1995438259 hasRelatedWork W2066417624 @default.
• W1995438259 hasRelatedWork W2066625719 @default.
• W1995438259 hasRelatedWork W2081667191 @default.
• W1995438259 hasRelatedWork W2091913905 @default.
• W1995438259 hasRelatedWork W2112801795 @default.
• W1995438259 hasRelatedWork W219391778 @default.
• W1995438259 hasRelatedWork W2341653829 @default.
• W1995438259 hasRelatedWork W2369139663 @default.
• W1995438259 hasRelatedWork W2388498347 @default.
• W1995438259 hasRelatedWork W2395791873 @default.
• W1995438259 hasRelatedWork W2412588134 @default.
• W1995438259 hasRelatedWork W2511288941 @default.
• W1995438259 hasRelatedWork W2517017657 @default.
• W1995438259 hasRelatedWork W2907737968 @default.

• next