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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995441314> ?p ?o ?g. }

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• W1995441314 abstract "We have previously shown that autoimmune gastritis can be elicited in mice by immunization with the gastric parietal cell H/K ATPase alpha beta heterodimer and that tolerance specifically induced to the H/K ATPase beta-subunit protects mice from the development of gastritis. Here we have identified the immunodominant gastritogenic epitope of the H/K ATPase beta-subunit (H/Kbeta). Epitope mapping was carried out with a panel of 21 overlapping peptides that spanned the entire sequence of the gastric H/K ATPase beta-subunit. T cells from gastric H/K ATPase-immunized mice responded to only one of the overlapping peptides, namely H/Kbeta253-277. Furthermore, a single subcutaneous immunization of 6-week-old BALB/c mice with the ATPase beta-subunit peptides resulted in a T-cell response to only H/Kbeta253-277. Multiple immunization with the overlapping H/K ATPase peptides demonstrated that H/Kbeta253-277 was capable of inducing a mononuclear infiltrate specifically within the gastric mucosa. We conclude that H/Kbeta253-277 is the dominant gastritogenic epitope of the gastric H/K ATPase." @default.
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• W1995441314 date "1999-01-01" @default.
• W1995441314 modified "2023-10-16" @default.
• W1995441314 title "Identification of a gastritogenic epitope of the H/K ATPase β‐subunit" @default.
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• W1995441314 doi "https://doi.org/10.1046/j.1365-2567.1999.00669.x" @default.
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