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• W1995444847 abstract "Le NO• est responsable d’une grande diversité d’effets sur l’organisme, tant bénéfiques que potentiellement délétères. Les effets bénéfiques sont principalement médiés par le NO• lui-même (par activation de la guanylate cyclase–voie cGMP-dépendante–et/ou S-nitrosylation) dans un microenvironnement biochimique donné, lorsqu’il est généré en quantité régulée et transitoire par les NO synthases (NOS, principalement endothéliales et neuronales). Par contre, lorsqu’il engendré en grandes quantités non régulées et prolongées par la NOS inductible, le NO• peut engendrer un stress oxydant et un stress nitrosant, par l’intermédiaire du peroxynitrite (réactions d’oxydation, de nitration et de nitrosylation oxydative) et du trioxide diazoté (réaction de nitrosation), respectivement. L’intégration des déterminants de l’effet net final du NO• est complexe et fait l’objet de recherches intensives dans l’espoir d’un traitement adapté, sélectif et titré. NO• exerts many effect on the organism, either beneficial or detrimental. Beneficial ones are mainly mediated by NO• itself (through activation of guanylyl cyclase—the cGMP-dependent pathway—or through S-nitrosylation) in a specific microenvironment, generated at low concentrations by endothelial or neuronal NO-synthases in a regulated manner. By contrast, prolonged and high-ouput inducible NOS-derived NO• may exert both oxidative and nitrosative stress, respectively through peroxynitrite-mediated oxidation, nitration and oxidative nitrosylation and through dinitrogen trioxide-mediated nitrosation. Integration of all determinants of the net effect of NO• is complex and is the topic of intensive research for potential adapted, selective and titrated treatment." @default.
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• W1995444847 date "2002-12-01" @default.
• W1995444847 modified "2023-09-27" @default.
• W1995444847 title "Les espèces réactives de l’azote : bénéfiques ou délétères ?" @default.
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• W1995444847 doi "https://doi.org/10.1016/s0985-0562(02)00167-x" @default.
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