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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995449886> ?p ?o ?g. }

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• W1995449886 abstract "A large series of N6-substituted-4'-thioadenosines were synthesized starting from D-gulonic-gamma-lactone, and structure-activity relationships were studied at the human A3 and other subtypes of adenosine receptors (ARs). 2-Chloro-substituted and 2-H analogues were compared. 2-Chloro-N6-methyl-4'-thioadenosine 19b was a highly potent and selective agonist (Ki=0.8+/-0.1 nM in binding) at the A3AR, and displayed the same relative efficacy in receptor activation as a known full agonist, Cl-IB-MECA. Most of N6-substituted-4'-thioadenosines were less potent in binding than the corresponding N6-substituted-adenosines or N6-substituted-4'-thioadenosine-5'-uronamides. N6-(3-Iodobenzyl) derivative 19g was demonstrated to be an A3AR-selective partial agonist displaying a Ki value of 3.2 nM." @default.
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• W1995449886 date "2006-07-15" @default.
• W1995449886 modified "2023-10-15" @default.
• W1995449886 title "Design, synthesis, and biological activity of N6-substituted-4′-thioadenosines at the human A3 adenosine receptor" @default.
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• W1995449886 doi "https://doi.org/10.1016/j.bmc.2006.03.030" @default.
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