Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995459439> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1995459439 endingPage "239" @default.
- W1995459439 startingPage "233" @default.
- W1995459439 abstract "To assess whether or not male reproductive toxicity can be evaluated in a 2-week administration study, boric acid was administered daily by oral gavage to male Jcl:Wistar rats at dosage levels of 0, 300 and 500 mg/kg for 2 and 4 weeks, and the results obtained with the two different treatment schedules were compared. After a 2-week administration, decreased testis weights were observed in the 500 mg/kg group. Histopathologically, exfoliation of round spermatids, retention of step 19 spermatids and increased numbers of residual body-like structures in the seminiferous tubules and cell debris in the cranial epididymal ducts were observed in the 300 and 500 mg/kg groups. Distorted cytoplasmic lobes of step 19 spermatids, debris in the seminiferous tubules and focal atrophy of the seminiferous tubules with multinucleated giant cells formation and necrosis of spermatocytes were also observed in the 500 mg/kg group. After a 4-week administration, testis and epididymis weights were decreased in the 300 and 500 mg/kg groups. Histopathological changes in the 300 mg/kg group were similar to those found in the 300 and 500 mg/kg groups after a 2-week administration. Diffuse atrophy of the seminiferous tubules was additionally observed in the 500 mg/kg group. These results suggest that 2 weeks is a sufficient treatment period for the detection of the testicular toxicity caused by boric acid." @default.
- W1995459439 created "2016-06-24" @default.
- W1995459439 creator A5007129211 @default.
- W1995459439 creator A5013731687 @default.
- W1995459439 creator A5017831409 @default.
- W1995459439 creator A5020740301 @default.
- W1995459439 creator A5052080737 @default.
- W1995459439 creator A5068919018 @default.
- W1995459439 date "2000-01-01" @default.
- W1995459439 modified "2023-09-27" @default.
- W1995459439 title "COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 24)TESTICULAR TOXICITY OF BORIC ACID AFTER 2-AND 4 -WEEK ADMINISTRATION PERIODS" @default.
- W1995459439 cites W1963519312 @default.
- W1995459439 cites W1965595172 @default.
- W1995459439 cites W1986065633 @default.
- W1995459439 cites W2012757283 @default.
- W1995459439 cites W2026915232 @default.
- W1995459439 cites W2109572007 @default.
- W1995459439 cites W2153073978 @default.
- W1995459439 cites W2320665809 @default.
- W1995459439 cites W2325343629 @default.
- W1995459439 doi "https://doi.org/10.2131/jts.25.specialissue_233" @default.
- W1995459439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11349449" @default.
- W1995459439 hasPublicationYear "2000" @default.
- W1995459439 type Work @default.
- W1995459439 sameAs 1995459439 @default.
- W1995459439 citedByCount "9" @default.
- W1995459439 countsByYear W19954594392012 @default.
- W1995459439 countsByYear W19954594392014 @default.
- W1995459439 countsByYear W19954594392015 @default.
- W1995459439 countsByYear W19954594392018 @default.
- W1995459439 countsByYear W19954594392020 @default.
- W1995459439 countsByYear W19954594392021 @default.
- W1995459439 crossrefType "journal-article" @default.
- W1995459439 hasAuthorship W1995459439A5007129211 @default.
- W1995459439 hasAuthorship W1995459439A5013731687 @default.
- W1995459439 hasAuthorship W1995459439A5017831409 @default.
- W1995459439 hasAuthorship W1995459439A5020740301 @default.
- W1995459439 hasAuthorship W1995459439A5052080737 @default.
- W1995459439 hasAuthorship W1995459439A5068919018 @default.
- W1995459439 hasBestOaLocation W19954594391 @default.
- W1995459439 hasConcept C123765429 @default.
- W1995459439 hasConcept C126322002 @default.
- W1995459439 hasConcept C134018914 @default.
- W1995459439 hasConcept C142724271 @default.
- W1995459439 hasConcept C16685009 @default.
- W1995459439 hasConcept C178790620 @default.
- W1995459439 hasConcept C185592680 @default.
- W1995459439 hasConcept C2776839515 @default.
- W1995459439 hasConcept C2777892665 @default.
- W1995459439 hasConcept C2779066085 @default.
- W1995459439 hasConcept C2781087480 @default.
- W1995459439 hasConcept C2781172350 @default.
- W1995459439 hasConcept C2781254305 @default.
- W1995459439 hasConcept C29730261 @default.
- W1995459439 hasConcept C503630168 @default.
- W1995459439 hasConcept C71924100 @default.
- W1995459439 hasConcept C77076574 @default.
- W1995459439 hasConcept C86803240 @default.
- W1995459439 hasConcept C99432707 @default.
- W1995459439 hasConceptScore W1995459439C123765429 @default.
- W1995459439 hasConceptScore W1995459439C126322002 @default.
- W1995459439 hasConceptScore W1995459439C134018914 @default.
- W1995459439 hasConceptScore W1995459439C142724271 @default.
- W1995459439 hasConceptScore W1995459439C16685009 @default.
- W1995459439 hasConceptScore W1995459439C178790620 @default.
- W1995459439 hasConceptScore W1995459439C185592680 @default.
- W1995459439 hasConceptScore W1995459439C2776839515 @default.
- W1995459439 hasConceptScore W1995459439C2777892665 @default.
- W1995459439 hasConceptScore W1995459439C2779066085 @default.
- W1995459439 hasConceptScore W1995459439C2781087480 @default.
- W1995459439 hasConceptScore W1995459439C2781172350 @default.
- W1995459439 hasConceptScore W1995459439C2781254305 @default.
- W1995459439 hasConceptScore W1995459439C29730261 @default.
- W1995459439 hasConceptScore W1995459439C503630168 @default.
- W1995459439 hasConceptScore W1995459439C71924100 @default.
- W1995459439 hasConceptScore W1995459439C77076574 @default.
- W1995459439 hasConceptScore W1995459439C86803240 @default.
- W1995459439 hasConceptScore W1995459439C99432707 @default.
- W1995459439 hasIssue "SpecialIssue" @default.
- W1995459439 hasLocation W19954594391 @default.
- W1995459439 hasLocation W19954594392 @default.
- W1995459439 hasOpenAccess W1995459439 @default.
- W1995459439 hasPrimaryLocation W19954594391 @default.
- W1995459439 hasRelatedWork W1990527470 @default.
- W1995459439 hasRelatedWork W1995459439 @default.
- W1995459439 hasRelatedWork W2031971887 @default.
- W1995459439 hasRelatedWork W2048234117 @default.
- W1995459439 hasRelatedWork W2083566566 @default.
- W1995459439 hasRelatedWork W2156381874 @default.
- W1995459439 hasRelatedWork W2320665809 @default.
- W1995459439 hasRelatedWork W2327960112 @default.
- W1995459439 hasRelatedWork W2365711933 @default.
- W1995459439 hasRelatedWork W2537536770 @default.
- W1995459439 hasVolume "25" @default.
- W1995459439 isParatext "false" @default.
- W1995459439 isRetracted "false" @default.
- W1995459439 magId "1995459439" @default.
- W1995459439 workType "article" @default.