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- W1995459504 abstract "Abstract We investigated the p38 MAPK role during sea urchin, Paracentrotus lividus, development. We found that at the morula stage, before the onset of skeletogenesis, p38 MAPK shows a peak of activity, and we tested whether p38 MAPK activity has any effect on skeletogenesis. By immunohistochemistry on whole-mount embryos we show the preferential localization of the active p38 form both in the presumptive PMCs and bilateral spiculo-genesis centers in control embryos, and in the radialized supernumerary spiculogenesis centers induced by NiCl2 treatment. By using SB203580, a p38 MAPK specific inhibitor, we show that p38 activity is required both for the initial triradiate spicule rudiments formation and for their correct elongation." @default.
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- W1995459504 date "2008-01-01" @default.
- W1995459504 modified "2023-10-16" @default.
- W1995459504 title "p38 MAPK activation is required for<i>Paracentrotus lividus</i>skeletogenesis" @default.
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- W1995459504 doi "https://doi.org/10.1080/00087114.2008.10589612" @default.
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