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- W1995466180 endingPage "10009" @default.
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- W1995466180 abstract "ABSTRACT V2/V3 conformational epitope antibodies that broadly neutralize HIV-1 (PG9 and PG16) have been recently described. Since an elicitation of previously known broadly neutralizing antibodies has proven elusive, the induction of antibodies with such specificity is an important goal for HIV-1 vaccine development. A critical question is which immunogens and vaccine formulations might be used to trigger and drive the development of memory B cell precursors with V2/V3 conformational epitope specificity. In this paper we identified a clonal lineage of four V2/V3 conformational epitope broadly neutralizing antibodies (CH01 to CH04) from an African HIV-1-infected broad neutralizer and inferred their common reverted unmutated ancestor (RUA) antibodies. While conformational epitope antibodies rarely bind recombinant Env monomers, a screen of 32 recombinant envelopes for binding to the CH01 to CH04 antibodies showed monoclonal antibody (MAb) binding to the E.A244 gp120 Env and to chronic Env AE.CM243; MAbs CH01 and CH02 also bound to transmitted/founder Env B.9021. CH01 to CH04 neutralized 38% to 49% of a panel of 91 HIV-1 tier 2 pseudoviruses, while the RUAs neutralized only 16% of HIV-1 isolates. Although the reverted unmutated ancestors showed restricted neutralizing activity, they retained the ability to bind to the E.A244 gp120 HIV-1 envelope with an affinity predicted to trigger B cell development. Thus, E.A244, B.9021, and AE.CM243 Envs are three potential immunogen candidates for studies aimed at defining strategies to induce V2/V3 conformational epitope-specific antibodies." @default.
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- W1995466180 date "2011-10-01" @default.
- W1995466180 modified "2023-10-18" @default.
- W1995466180 title "Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors" @default.
- W1995466180 cites W1510119750 @default.
- W1995466180 cites W1534972788 @default.
- W1995466180 cites W1794879226 @default.
- W1995466180 cites W1939108455 @default.
- W1995466180 cites W1971233211 @default.
- W1995466180 cites W1972143601 @default.
- W1995466180 cites W1974273518 @default.
- W1995466180 cites W1981981290 @default.
- W1995466180 cites W1991497659 @default.
- W1995466180 cites W1996626942 @default.
- W1995466180 cites W1997677784 @default.
- W1995466180 cites W1998406600 @default.
- W1995466180 cites W2007075170 @default.
- W1995466180 cites W2009151161 @default.
- W1995466180 cites W2010996470 @default.
- W1995466180 cites W2014334082 @default.
- W1995466180 cites W2018123062 @default.
- W1995466180 cites W2034160159 @default.
- W1995466180 cites W2040878504 @default.
- W1995466180 cites W2051364248 @default.
- W1995466180 cites W2065327430 @default.
- W1995466180 cites W2071461138 @default.
- W1995466180 cites W2072901265 @default.
- W1995466180 cites W2081820824 @default.
- W1995466180 cites W2083627780 @default.
- W1995466180 cites W2083726777 @default.
- W1995466180 cites W2084310667 @default.
- W1995466180 cites W2089766500 @default.
- W1995466180 cites W2090763940 @default.
- W1995466180 cites W2095910488 @default.
- W1995466180 cites W2096387523 @default.
- W1995466180 cites W2097594050 @default.
- W1995466180 cites W2098497060 @default.
- W1995466180 cites W2103712192 @default.
- W1995466180 cites W2104487408 @default.
- W1995466180 cites W2105336865 @default.
- W1995466180 cites W2106228977 @default.
- W1995466180 cites W2108868448 @default.
- W1995466180 cites W2111098506 @default.
- W1995466180 cites W2119779320 @default.
- W1995466180 cites W2119923823 @default.
- W1995466180 cites W2121016876 @default.
- W1995466180 cites W2121096721 @default.
- W1995466180 cites W2122210861 @default.
- W1995466180 cites W2125677968 @default.
- W1995466180 cites W2132783668 @default.
- W1995466180 cites W2133527269 @default.
- W1995466180 cites W2134312805 @default.
- W1995466180 cites W2134544592 @default.
- W1995466180 cites W2135151522 @default.
- W1995466180 cites W2152048324 @default.
- W1995466180 cites W2152440860 @default.
- W1995466180 cites W2155922867 @default.
- W1995466180 cites W2156469184 @default.
- W1995466180 cites W2157820405 @default.
- W1995466180 cites W2159795515 @default.
- W1995466180 cites W2163558461 @default.
- W1995466180 cites W2169367715 @default.
- W1995466180 doi "https://doi.org/10.1128/jvi.05045-11" @default.