Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995475065> ?p ?o ?g. }
- W1995475065 abstract "Bipolar disorder (BD) is a psychiatric illness defined by pathological alterations between the mood states of mania and depression, causing disability, imposing healthcare costs and elevating the risk of suicide. Although effective treatments for BD exist, variability in outcomes leads to a large number of treatment failures, typically followed by a trial and error process of medication switches that can take years. Pharmacogenetic testing (PGT), by tailoring drug choice to an individual, may personalize and expedite treatment so as to identify more rapidly medications well suited to individual BD patients. A number of associations have been made in BD between medication response phenotypes and specific genetic markers. However, to date clinical adoption of PGT has been limited, often citing questions that must be answered before it can be widely utilized. These include: What are the requirements of supporting evidence? How large is a clinically relevant effect? What degree of specificity and sensitivity are required? Does a given marker influence decision making and have clinical utility? In many cases, the answers to these questions remain unknown, and ultimately, the question of whether PGT is valid and useful must be determined empirically. Towards this aim, we have reviewed the literature and selected drug-genotype associations with the strongest evidence for utility in BD. Based upon these findings, we propose a preliminary panel for use in PGT, and a method by which the results of a PGT panel can be integrated for clinical interpretation. Finally, we argue that based on the sufficiency of accumulated evidence, PGT implementation studies are now warranted. We propose and discuss the design for a randomized clinical trial to test the use of PGT in the treatment of BD." @default.
- W1995475065 created "2016-06-24" @default.
- W1995475065 creator A5016043879 @default.
- W1995475065 creator A5037074544 @default.
- W1995475065 creator A5059158920 @default.
- W1995475065 creator A5083259054 @default.
- W1995475065 date "2014-05-30" @default.
- W1995475065 modified "2023-10-09" @default.
- W1995475065 title "Towards the clinical implementation of pharmacogenetics in bipolar disorder" @default.
- W1995475065 cites W1485363052 @default.
- W1995475065 cites W1489716577 @default.
- W1995475065 cites W1505450507 @default.
- W1995475065 cites W1553261973 @default.
- W1995475065 cites W1580174237 @default.
- W1995475065 cites W1679888853 @default.
- W1995475065 cites W1766115599 @default.
- W1995475065 cites W1838357706 @default.
- W1995475065 cites W1890987751 @default.
- W1995475065 cites W1899399637 @default.
- W1995475065 cites W1910711810 @default.
- W1995475065 cites W1963549425 @default.
- W1995475065 cites W1963984456 @default.
- W1995475065 cites W1964979617 @default.
- W1995475065 cites W1965474078 @default.
- W1995475065 cites W1966925569 @default.
- W1995475065 cites W1970603007 @default.
- W1995475065 cites W1970821395 @default.
- W1995475065 cites W1970924226 @default.
- W1995475065 cites W1971946342 @default.
- W1995475065 cites W1972039708 @default.
- W1995475065 cites W1972278987 @default.
- W1995475065 cites W1973178798 @default.
- W1995475065 cites W1974639348 @default.
- W1995475065 cites W1976824439 @default.
- W1995475065 cites W1978709168 @default.
- W1995475065 cites W1978742008 @default.
- W1995475065 cites W1979825096 @default.
- W1995475065 cites W1980653339 @default.
- W1995475065 cites W1981077350 @default.
- W1995475065 cites W1981896133 @default.
- W1995475065 cites W1982886582 @default.
- W1995475065 cites W1985517071 @default.
- W1995475065 cites W1986307811 @default.
- W1995475065 cites W1987837380 @default.
- W1995475065 cites W1988230174 @default.
- W1995475065 cites W1993588417 @default.
- W1995475065 cites W1994337442 @default.
- W1995475065 cites W1994862314 @default.
- W1995475065 cites W1996667997 @default.
- W1995475065 cites W1998122483 @default.
- W1995475065 cites W2001657113 @default.
- W1995475065 cites W2001781507 @default.
- W1995475065 cites W2002366369 @default.
- W1995475065 cites W2003203210 @default.
- W1995475065 cites W2003385727 @default.
- W1995475065 cites W2004244289 @default.
- W1995475065 cites W2004616934 @default.
- W1995475065 cites W2005534453 @default.
- W1995475065 cites W2007781929 @default.
- W1995475065 cites W2007789051 @default.
- W1995475065 cites W2008033091 @default.
- W1995475065 cites W2008498668 @default.
- W1995475065 cites W2009886463 @default.
- W1995475065 cites W2010425739 @default.
- W1995475065 cites W2011797837 @default.
- W1995475065 cites W2012453845 @default.
- W1995475065 cites W2014007437 @default.
- W1995475065 cites W2015638257 @default.
- W1995475065 cites W2016650069 @default.
- W1995475065 cites W2016911934 @default.
- W1995475065 cites W2019878424 @default.
- W1995475065 cites W2022293269 @default.
- W1995475065 cites W2022452929 @default.
- W1995475065 cites W2025779989 @default.
- W1995475065 cites W2026102869 @default.
- W1995475065 cites W2027689592 @default.
- W1995475065 cites W2029995473 @default.
- W1995475065 cites W2033674020 @default.
- W1995475065 cites W2034212588 @default.
- W1995475065 cites W2037962204 @default.
- W1995475065 cites W2041379086 @default.
- W1995475065 cites W2044827759 @default.
- W1995475065 cites W2049902892 @default.
- W1995475065 cites W2050070110 @default.
- W1995475065 cites W2051788298 @default.
- W1995475065 cites W2052668465 @default.
- W1995475065 cites W2053850273 @default.
- W1995475065 cites W2054219118 @default.
- W1995475065 cites W2055160461 @default.
- W1995475065 cites W2057653506 @default.
- W1995475065 cites W2059483509 @default.
- W1995475065 cites W2061800286 @default.
- W1995475065 cites W2062935033 @default.
- W1995475065 cites W2063249326 @default.
- W1995475065 cites W2064388491 @default.
- W1995475065 cites W2065844121 @default.
- W1995475065 cites W2069365138 @default.
- W1995475065 cites W2072157236 @default.
- W1995475065 cites W2072815115 @default.
- W1995475065 cites W2074404972 @default.