Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995475535> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1995475535 endingPage "242" @default.
- W1995475535 startingPage "239" @default.
- W1995475535 abstract "Background: Sulphasalazine is used for the long-term maintenance therapy of ulcerative colitis to prevent the relapse of symptoms. However, its clinical use is often restricted by its serious adverse effects. Objective: Leucopenia occurred in a patient with severe renal dysfunction after administration of sulphasalazine. The present study was designed to examine whether the adverse event was associated with a disability in the metabolism of sulphasalazine. Subject: A 29-year-old male patient with ulcerative colitis, who underwent haemodialysis thrice a week because of severe renal dysfunction. The chief complaint was diarrhoea. Methods: Serum concentrations of three major metabolites of sulphasalazine, (5-aminosalicylic acid, sulphapyridine and N-acetyl-sulphapyridine), were measured. The polymorphism of N-acetyltransferase 2, an enzyme that metabolizes sulphapyridine, was also determined by polymerase chain reaction. Results: The trough levels of 5-aminosalicylic acid, sulphapyridine and N-acetyl-sulphapyridine were 0·77–1·45 μg/mL, 31·20–39·25 μg/mL and 14·19–15·03 μg/mL, respectively. The gene diagnosis of N-acetyltransferase 2 suggested that the type was classified as NAT2*6A/*7B, indicating that the patient was a slow acetylator. Conclusion: The patient was a slow acetylator, which might lead to a rise in the serum sulphapyridine concentration. Moreover, the decrease in protein binding of sulphasalazine as a result of severe renal dysfunction might have potentiated the effect because of the extremely high protein binding of this compound. Thus, it is most likely that these two factors contributed to the sulphasalazine-induced leucopenia." @default.
- W1995475535 created "2016-06-24" @default.
- W1995475535 creator A5007218728 @default.
- W1995475535 creator A5013232618 @default.
- W1995475535 creator A5013483206 @default.
- W1995475535 creator A5020799696 @default.
- W1995475535 creator A5023687497 @default.
- W1995475535 creator A5033385933 @default.
- W1995475535 creator A5053189401 @default.
- W1995475535 creator A5056078811 @default.
- W1995475535 date "2003-06-01" @default.
- W1995475535 modified "2023-09-25" @default.
- W1995475535 title "Sulphasalazine-induced leucopenia in a patient with renal dysfunction" @default.
- W1995475535 cites W1603613420 @default.
- W1995475535 cites W1997310223 @default.
- W1995475535 cites W2001257866 @default.
- W1995475535 cites W2032447921 @default.
- W1995475535 cites W2045538930 @default.
- W1995475535 cites W2065780155 @default.
- W1995475535 cites W2090568923 @default.
- W1995475535 cites W2096326818 @default.
- W1995475535 cites W2114959701 @default.
- W1995475535 cites W2150323980 @default.
- W1995475535 cites W2415775034 @default.
- W1995475535 doi "https://doi.org/10.1046/j.1365-2710.2003.00484.x" @default.
- W1995475535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12795783" @default.
- W1995475535 hasPublicationYear "2003" @default.
- W1995475535 type Work @default.
- W1995475535 sameAs 1995475535 @default.
- W1995475535 citedByCount "15" @default.
- W1995475535 countsByYear W19954755352012 @default.
- W1995475535 countsByYear W19954755352017 @default.
- W1995475535 countsByYear W19954755352020 @default.
- W1995475535 countsByYear W19954755352022 @default.
- W1995475535 crossrefType "journal-article" @default.
- W1995475535 hasAuthorship W1995475535A5007218728 @default.
- W1995475535 hasAuthorship W1995475535A5013232618 @default.
- W1995475535 hasAuthorship W1995475535A5013483206 @default.
- W1995475535 hasAuthorship W1995475535A5020799696 @default.
- W1995475535 hasAuthorship W1995475535A5023687497 @default.
- W1995475535 hasAuthorship W1995475535A5033385933 @default.
- W1995475535 hasAuthorship W1995475535A5053189401 @default.
- W1995475535 hasAuthorship W1995475535A5056078811 @default.
- W1995475535 hasBestOaLocation W19954755351 @default.
- W1995475535 hasConcept C126322002 @default.
- W1995475535 hasConcept C178790620 @default.
- W1995475535 hasConcept C185592680 @default.
- W1995475535 hasConcept C197934379 @default.
- W1995475535 hasConcept C2776206795 @default.
- W1995475535 hasConcept C2777031107 @default.
- W1995475535 hasConcept C2779134260 @default.
- W1995475535 hasConcept C2779561371 @default.
- W1995475535 hasConcept C2780091579 @default.
- W1995475535 hasConcept C2780479503 @default.
- W1995475535 hasConcept C71924100 @default.
- W1995475535 hasConcept C90924648 @default.
- W1995475535 hasConceptScore W1995475535C126322002 @default.
- W1995475535 hasConceptScore W1995475535C178790620 @default.
- W1995475535 hasConceptScore W1995475535C185592680 @default.
- W1995475535 hasConceptScore W1995475535C197934379 @default.
- W1995475535 hasConceptScore W1995475535C2776206795 @default.
- W1995475535 hasConceptScore W1995475535C2777031107 @default.
- W1995475535 hasConceptScore W1995475535C2779134260 @default.
- W1995475535 hasConceptScore W1995475535C2779561371 @default.
- W1995475535 hasConceptScore W1995475535C2780091579 @default.
- W1995475535 hasConceptScore W1995475535C2780479503 @default.
- W1995475535 hasConceptScore W1995475535C71924100 @default.
- W1995475535 hasConceptScore W1995475535C90924648 @default.
- W1995475535 hasIssue "3" @default.
- W1995475535 hasLocation W19954755351 @default.
- W1995475535 hasLocation W19954755352 @default.
- W1995475535 hasOpenAccess W1995475535 @default.
- W1995475535 hasPrimaryLocation W19954755351 @default.
- W1995475535 hasRelatedWork W143263338 @default.
- W1995475535 hasRelatedWork W1985569360 @default.
- W1995475535 hasRelatedWork W1989740133 @default.
- W1995475535 hasRelatedWork W2073759704 @default.
- W1995475535 hasRelatedWork W2138179347 @default.
- W1995475535 hasRelatedWork W2252675334 @default.
- W1995475535 hasRelatedWork W2263605371 @default.
- W1995475535 hasRelatedWork W2407927805 @default.
- W1995475535 hasRelatedWork W2999527238 @default.
- W1995475535 hasRelatedWork W3014832808 @default.
- W1995475535 hasVolume "28" @default.
- W1995475535 isParatext "false" @default.
- W1995475535 isRetracted "false" @default.
- W1995475535 magId "1995475535" @default.
- W1995475535 workType "article" @default.