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- W1995475543 abstract "Administration of clofibrate frequently reduces serum cholesterol levels in hypercholesterolemic swine to near the base level within a few weeks even when the hypercholesterolemic diet is continued. The current study was designed to investigate hepatic ultrastructural changes that might be associated with the hypocholesterolemic effect of clofibrate. Characteristic ultrastructural changes were observed in 17% of hepatocellular mitochondria after 6 wk of clofibrate treatment. The most frequent mitochondrial alteration was the presence of discrete bundles of tubular or spiral structures which appeared at random in orientation. The number of microbodies increased moderately but no structural changes were noted." @default.
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- W1995475543 date "1974-06-01" @default.
- W1995475543 modified "2023-09-27" @default.
- W1995475543 title "Ultrastructural study of hepatic mitochondrial abnormality in swine treated with clofibrate" @default.
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- W1995475543 doi "https://doi.org/10.1016/0014-4800(74)90068-9" @default.
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