FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995483636> ?p ?o ?g. }

• W1995483636 endingPage "5006" @default.
• W1995483636 startingPage "4999" @default.
• W1995483636 abstract "Polyphenol-rich apple extracts have been reported to suppress human colon cancer cell growth in vitro. The protein kinase C (PKC) is among the signaling elements known to play an important role in colon carcinogenesis. In the present study, we investigated whether apple polyphenols affect PKC activity and induce apoptosis in the human colon carcinoma cell line HT29. A polyphenol-rich apple juice extract (AE02) was shown to inhibit cytosolic PKC activity in a cell-free system. In contrast, incubation of HT29 cells for 1 or 3 h with AE02 up to 2 mg/mL did not affect the cytosolic PKC activity. After prolonged incubation (24 h), cytosolic PKC activity was modulated, albeit a u-shaped curve of effectiveness was observed, with an initial inhibitory effect followed by the recurrence and even induction of enzyme activity. Concomitantly, in the cytosol, a significant decrease of the protein levels of PKCalpha, PKCbetaII, and PKCgamma together with a significant increase of a proapoptotic PKCdelta fragment was observed. However, the effects on the protein levels of these PKC isoforms in the cytosol were not associated with translocation between the different cellular compartments but might instead result from the onset of apoptosis. Indeed, the treatment with AE02 was shown to induce apoptosis by the activation of caspase-3, DNA fragmentation, and cleavage of poly(ADP ribose) polymerase. So far, identified and available constituents of the apple extract did not contribute substantially to the observed effects on PKC and apoptosis induction. In summary, apple polyphenols were found to inhibit PKC activity in a cell-free system. However, our results indicate that within intact cells PKC does not represent the primary target of apple polyphenols but appears to be affected in the course of apoptosis induction." @default.
• W1995483636 created "2016-06-24" @default.
• W1995483636 creator A5003237351 @default.
• W1995483636 creator A5007415732 @default.
• W1995483636 creator A5013508239 @default.
• W1995483636 creator A5039475936 @default.
• W1995483636 creator A5047497411 @default.
• W1995483636 date "2007-06-01" @default.
• W1995483636 modified "2023-09-27" @default.
• W1995483636 title "Apple Polyphenols Affect Protein Kinase C Activity and the Onset of Apoptosis in Human Colon Carcinoma Cells" @default.
• W1995483636 cites W1564012501 @default.
• W1995483636 cites W1577885098 @default.
• W1995483636 cites W1767727568 @default.
• W1995483636 cites W1842412546 @default.
• W1995483636 cites W1969150166 @default.
• W1995483636 cites W1976367795 @default.
• W1995483636 cites W1976819839 @default.
• W1995483636 cites W1981241274 @default.
• W1995483636 cites W1995476301 @default.
• W1995483636 cites W2004294452 @default.
• W1995483636 cites W2007468478 @default.
• W1995483636 cites W2013634259 @default.
• W1995483636 cites W2019134304 @default.
• W1995483636 cites W2038906343 @default.
• W1995483636 cites W2060066334 @default.
• W1995483636 cites W2060479161 @default.
• W1995483636 cites W2061163368 @default.
• W1995483636 cites W2078166953 @default.
• W1995483636 cites W2087865871 @default.
• W1995483636 cites W2101634275 @default.
• W1995483636 cites W2105869334 @default.
• W1995483636 cites W2127892423 @default.
• W1995483636 cites W2128878512 @default.
• W1995483636 cites W2141956082 @default.
• W1995483636 cites W4293247451 @default.
• W1995483636 cites W75781627 @default.
• W1995483636 doi "https://doi.org/10.1021/jf063158x" @default.
• W1995483636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17542601" @default.
• W1995483636 hasPublicationYear "2007" @default.
• W1995483636 type Work @default.
• W1995483636 sameAs 1995483636 @default.
• W1995483636 citedByCount "61" @default.
• W1995483636 countsByYear W19954836362012 @default.
• W1995483636 countsByYear W19954836362013 @default.
• W1995483636 countsByYear W19954836362014 @default.
• W1995483636 countsByYear W19954836362015 @default.
• W1995483636 countsByYear W19954836362016 @default.
• W1995483636 countsByYear W19954836362017 @default.
• W1995483636 countsByYear W19954836362018 @default.
• W1995483636 countsByYear W19954836362019 @default.
• W1995483636 countsByYear W19954836362020 @default.
• W1995483636 countsByYear W19954836362021 @default.
• W1995483636 countsByYear W19954836362022 @default.
• W1995483636 countsByYear W19954836362023 @default.
• W1995483636 crossrefType "journal-article" @default.
• W1995483636 hasAuthorship W1995483636A5003237351 @default.
• W1995483636 hasAuthorship W1995483636A5007415732 @default.
• W1995483636 hasAuthorship W1995483636A5013508239 @default.
• W1995483636 hasAuthorship W1995483636A5039475936 @default.
• W1995483636 hasAuthorship W1995483636A5047497411 @default.
• W1995483636 hasConcept C12519072 @default.
• W1995483636 hasConcept C153911025 @default.
• W1995483636 hasConcept C181199279 @default.
• W1995483636 hasConcept C182979987 @default.
• W1995483636 hasConcept C184235292 @default.
• W1995483636 hasConcept C190283241 @default.
• W1995483636 hasConcept C195794163 @default.
• W1995483636 hasConcept C2778004101 @default.
• W1995483636 hasConcept C31573885 @default.
• W1995483636 hasConcept C43759708 @default.
• W1995483636 hasConcept C54355233 @default.
• W1995483636 hasConcept C55493867 @default.
• W1995483636 hasConcept C70899900 @default.
• W1995483636 hasConcept C81885089 @default.
• W1995483636 hasConcept C82381507 @default.
• W1995483636 hasConcept C86803240 @default.
• W1995483636 hasConcept C98424977 @default.
• W1995483636 hasConcept C98539663 @default.
• W1995483636 hasConceptScore W1995483636C12519072 @default.
• W1995483636 hasConceptScore W1995483636C153911025 @default.
• W1995483636 hasConceptScore W1995483636C181199279 @default.
• W1995483636 hasConceptScore W1995483636C182979987 @default.
• W1995483636 hasConceptScore W1995483636C184235292 @default.
• W1995483636 hasConceptScore W1995483636C190283241 @default.
• W1995483636 hasConceptScore W1995483636C195794163 @default.
• W1995483636 hasConceptScore W1995483636C2778004101 @default.
• W1995483636 hasConceptScore W1995483636C31573885 @default.
• W1995483636 hasConceptScore W1995483636C43759708 @default.
• W1995483636 hasConceptScore W1995483636C54355233 @default.
• W1995483636 hasConceptScore W1995483636C55493867 @default.
• W1995483636 hasConceptScore W1995483636C70899900 @default.
• W1995483636 hasConceptScore W1995483636C81885089 @default.
• W1995483636 hasConceptScore W1995483636C82381507 @default.
• W1995483636 hasConceptScore W1995483636C86803240 @default.
• W1995483636 hasConceptScore W1995483636C98424977 @default.
• W1995483636 hasConceptScore W1995483636C98539663 @default.
• W1995483636 hasIssue "13" @default.
• W1995483636 hasLocation W19954836361 @default.

• next